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lysA diaminopimelate decarboxylase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947313, updated on 26-Mar-2025
Official Symbol
lysA
Official Full Name
diaminopimelate decarboxylase
Primary source
ECOCYC:EG10549
Locus tag
b2838
See related
ASAP:ABE-0009309
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2836
Summary
Diaminopimelate decarboxylase (LysA) catalyzes the last step in lysine biosynthesis, converting meso-diaminopimelate to lysine. [More information is available at EcoCyc: EG10549].
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Sequence:
NC_000913.3 (2977637..2978899, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DNA-binding transcriptional dual regulator GalR Neighboring gene DNA-binding transcriptional dual regulator LysR Neighboring gene amino acid racemase YgeA Neighboring gene arabinose:H(+) symporter

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Diaminopimelic acid decarboxylase in cells and extracts of Escherichia coli and Aerobacter aerogenes. DEWEY DL, et al. Biochem J, 1954 Dec. PMID 13229999, Free PMC Article
  2. The use of an Escherichia coli Lys- auxotroph to assay nutritionally available lysine in biological materials. Payne JW, et al. J Appl Bacteriol, 1977 Apr. PMID 326744
  3. The regulation of diaminopimelate decarboxylase activity in Escherichia coli strain w. White PJ. J Gen Microbiol, 1976 Sep. PMID 789815
  4. Variation of activity of bacterial diaminopimelate decarboxylase under different conditions of growth. White PJ, et al. Biochem J, 1964 Jun. PMID 4953932, Free PMC Article
  5. Construction of hybrid plasmids containing the lysA gene of Escherichia coli: studies of expression in Escherichia coli and Saccharomyces cerevisiae. Chenais J, et al. Mol Gen Genet, 1981. PMID 6272062

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables diaminopimelate decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables diaminopimelate decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables diaminopimelate decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lysine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lysine biosynthetic process via diaminopimelate IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lysine biosynthetic process via diaminopimelate IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lysine biosynthetic process via diaminopimelate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Preferred Names
diaminopimelate decarboxylase
NP_417315.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2977637..2978899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417315.1 diaminopimelate decarboxylase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417315.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N0IMT7
    Conserved Domains (1) summary
    PRK11165
    Location:1 → 411
    PRK11165; diaminopimelate decarboxylase; Provisional
Nucleotide Protein
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