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lysR DNA-binding transcriptional dual regulator LysR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947311, updated on 26-Mar-2025
Official Symbol
lysR
Official Full Name
DNA-binding transcriptional dual regulator LysR
Primary source
ECOCYC:EG10551
Locus tag
b2839
See related
ASAP:ABE-0009313
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2837
Summary
"Lysine Regulator," LysR, is negatively autoregulated and coordinately activates transcription of the divergent gene which encodes the enzyme that catalyzes the last step in lysine biosynthesis . [More information is available at EcoCyc: EG10551].
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Sequence:
NC_000913.3 (2979021..2979956)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator GalR Neighboring gene diaminopimelate decarboxylase Neighboring gene amino acid racemase YgeA Neighboring gene arabinose:H(+) symporter Neighboring gene putative 2-keto-3-deoxy-D-gluconate dehydrogenase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Specificity of the E. coli LysR-type transcriptional regulators. Knapp GS, et al. PLoS One, 2010 Dec 20. PMID 21187915, Free PMC Article
  2. Regulatory pattern of the Escherichia coli lysA gene: expression of chromosomal lysA-lacZ fusions. Stragier P, et al. J Bacteriol, 1983 Dec. PMID 6417111, Free PMC Article
  3. Regulation of diaminopimelate decarboxylase synthesis in Escherichia coli. I. Identification of a lysR gene encoding an activator of the lysA gene. Stragier P, et al. J Mol Biol, 1983 Aug 5. PMID 6411928
  4. Regulation of diaminopimelate decarboxylase synthesis in Escherichia coli. II. Nucleotide sequence of the lysA gene and its regulatory region. Stragier P, et al. J Mol Biol, 1983 Aug 5. PMID 6350601
  5. A large family of bacterial activator proteins. Henikoff S, et al. Proc Natl Acad Sci U S A, 1988 Sep. PMID 3413113, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in lysine biosynthetic process via diaminopimelate IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lysine biosynthetic process via diaminopimelate IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lysine biosynthetic process via diaminopimelate IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
DNA-binding transcriptional dual regulator LysR

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2979021..2979956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417316.1 DNA-binding transcriptional dual regulator LysR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417316.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2H4TVI6
    Conserved Domains (1) summary
    PRK11013
    Location:1 → 309
    PRK11013; DNA-binding transcriptional regulator LysR; Provisional
Nucleotide Protein
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