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recC exodeoxyribonuclease V subunit RecC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947294, updated on 4-Feb-2026
Official Symbol
recC
Official Full Name
exodeoxyribonuclease V subunit RecC
Primary source
ECOCYC:EG10825
Locus tag
b2822
See related
ASAP:ABE-0009255
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2818
Summary
RecBCD is a bipolar helicase. [More information is available at EcoGene: EG10825]. Exodeoxyribonuclease V gamma chain. [More information is available at EcoCyc: EG10825].
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Sequence:
NC_000913.3 (2959060..2962428, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene exodeoxyribonuclease V subunit RecD Neighboring gene exodeoxyribonuclease V subunit RecB Neighboring gene protease 3 Neighboring gene prepilin-type N-terminal cleavage/methylation domain-containing protein PpdC Neighboring gene DUF2509 domain-containing protein YgdB Neighboring gene prepilin-type N-terminal cleavage/methylation domain-containing protein PpdB Neighboring gene prepilin-type N-terminal cleavage/methylation domain-containing protein PpdA

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Alteration of χ recognition by RecBCD reveals a regulated molecular latch and suggests a channel-bypass mechanism for biological control. Yang L, et al. Proc Natl Acad Sci U S A, 2012 Jun 5. PMID 22603793, Free PMC Article
  2. Transfection of Escherichia coli spheroplasts. V. Activity of recBC nuclease in rec+ and rec minus spheroplasts measured with different forms of bacteriophage DNA. Benzinger R, et al. J Virol, 1975 Apr. PMID 123277, Free PMC Article
  3. A domain of RecC required for assembly of the regulatory RecD subunit into the Escherichia coli RecBCD holoenzyme. Amundsen SK, et al. Genetics, 2002 Jun. PMID 12072448, Free PMC Article
  4. Translocation step size and mechanism of the RecBC DNA helicase. Bianco PR, et al. Nature, 2000 May 18. PMID 10830968
  5. Kinetic control of Mg2+-dependent melting of duplex DNA ends by Escherichia coli RecBC. Wong CJ, et al. J Mol Biol, 2008 May 9. PMID 18395743, Free PMC Article

See all (134) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chi hotspot control of RecBCD helicase-nuclease by long-range intramolecular signaling.
    Title: Chi hotspot control of RecBCD helicase-nuclease by long-range intramolecular signaling.
  2. Data show that RecBCD and its subunits are able to generate forces up to 25-40 pN without a significant effect on their velocity.
    Title: Synergy between RecBCD subunits is essential for efficient DNA unwinding.
  3. Data show genetic analysis RecBCD and naive adaptation in Escherichia coli.
    Title: CRISPR-Cas adaptation in Escherichia coli requires RecBCD helicase but not nuclease activity, is independent of homologous recombination, and is antagonized by 5' ssDNA exonucleases.
  4. Extension of the 5'-tail of the unwound duplex induces a large conformational change in the RecD subunit, that is transferred through the RecC subunit to activate the nuclease domain of the RecB subunit.
    Title: Mechanism for nuclease regulation in RecBCD.
  5. A new role of the RecBCD complex in the processing of DNA single-strand gaps that are generated at DNA replication-blocking lesions: independently of its nuclease or helicase activities, the entire RecBCD complex is required for recombinational repair of the gap and efficient translesion synthesis.
    Title: A non-catalytic role of RecBCD in homology directed gap repair and translesion synthesis.
  6. Sequence-dependent nanometer-scale conformational dynamics of individual RecBCD-DNA complexes has been reported.
    Title: Sequence-dependent nanometer-scale conformational dynamics of individual RecBCD-DNA complexes.
  7. RecBCD is required to complete chromosomal replication. (Review)
    Title: RecBCD is required to complete chromosomal replication: Implications for double-strand break frequencies and repair mechanisms.
  8. Studies characterized the chromosomal replication and degradation patterns during thymine starvation in Rec+ cells, as well as in the recA and recBCD mutants.
    Title: Disintegration of nascent replication bubbles during thymine starvation triggers RecA- and RecBCD-dependent replication origin destruction.
  9. Recognition of a single-stranded DNA sequence switches the translocating RecBCD from a destructive nuclease to a constructive component of recombinational DNA repair.
    Title: Alteration of χ recognition by RecBCD reveals a regulated molecular latch and suggests a channel-bypass mechanism for biological control.
  10. Study hypothesized that RuvAB catalyzes replication fork reversal, RecJ and XonA blunt the double-strand end, and then RecBCD loads RecA4142 onto this end to produce SOS(Con) expression.
    Title: RecA4142 causes SOS constitutive expression by loading onto reversed replication forks in Escherichia coli K-12.
Submit: New GeneRIF Correction See all GeneRIFs (19)
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity, acting on DNA IEA
Inferred from Electronic Annotation
more info
  
enables exodeoxyribonuclease V activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables exodeoxyribonuclease V activity IEA
Inferred from Electronic Annotation
more info
  
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA recombination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within DNA recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in clearance of foreign intracellular DNA IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within double-strand break repair via homologous recombination TAS
Traceable Author Statement
more info
 PubMed 
involved_in recombinational repair IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to radiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of exodeoxyribonuclease V complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of exodeoxyribonuclease V complex IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
exodeoxyribonuclease V subunit RecC
NP_417299.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2959060..2962428 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417299.1 exodeoxyribonuclease V subunit RecC

    See identical proteins and their annotated locations for NP_417299.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7H9NBM4
    Conserved Domains (1) summary
    PRK11069
    Location:1 → 1122
    recC; exodeoxyribonuclease V subunit gamma
Nucleotide Protein
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