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amiC N-acetylmuramoyl-L-alanine amidase C [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947293, updated on 6-Jul-2026
Official Symbol
amiC
Official Full Name
N-acetylmuramoyl-L-alanine amidase C
Primary source
ECOCYC:G7458
Locus tag
b2817
See related
ASAP:ABE-0009238
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2813; ygdN
Summary
Verified Tat substrate: [More information is available at EcoGene: EG13086]. AmiC is an N-acetylmuramyl-L-alanine amidase, which cleaves the peptide moiety from N-acetylmuramic acid, removing murein crosslinks. [More information is available at EcoCyc: G7458].
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Sequence:
NC_000913.3 (2947757..2949010, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-Met Neighboring gene tRNA-Met Neighboring gene N-acetylglutamate synthase Neighboring gene exodeoxyribonuclease V subunit RecD Neighboring gene exodeoxyribonuclease V subunit RecB

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Oligomerization of the amide sensor protein AmiC by x-ray and neutron scattering and molecular modeling. Chamberlain D, et al. Biochemistry, 1997 Jul 1. PMID 9201949
  2. Proteolytic processing of Escherichia coli twin-arginine signal peptides by LepB. Lüke I, et al. Arch Microbiol, 2009 Dec. PMID 19809807
  3. Visualization of proteins in intact cells with a clonable tag for electron microscopy. Diestra E, et al. J Struct Biol, 2009 Mar. PMID 19114107
  4. Activity of three murein hydrolases during the cell division cycle of Escherichia coli K-12 as measured in toluene-treated cells. Beck BD, et al. J Bacteriol, 1976 Jun. PMID 780345, Free PMC Article
  5. Daughter cell separation by penicillin-binding proteins and peptidoglycan amidases in Escherichia coli. Priyadarshini R, et al. J Bacteriol, 2006 Aug. PMID 16855223, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Periplasmic amidases AmiC and AmiA, secreted by the twin arginine transport (Tat) pathway, are localized to the cytoplasm in Escherichia coli YqjA and YghB double mutant cells.
    Title: Inefficient Tat-dependent export of periplasmic amidases in an Escherichia coli strain with mutations in two DedA family genes.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables N-acetylmuramoyl-L-alanine amidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetylmuramoyl-L-alanine amidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-acetylmuramoyl-L-alanine amidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in FtsZ-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within FtsZ-dependent cytokinesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cell division EXP
Inferred from Experiment
more info
 PubMed 
involved_in peptidoglycan catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in outer membrane-bounded periplasmic space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in outer membrane-bounded periplasmic space RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
N-acetylmuramoyl-L-alanine amidase C
NP_417294.4

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2947757..2949010 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417294.4 N-acetylmuramoyl-L-alanine amidase C

    See identical proteins and their annotated locations for NP_417294.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0H2Z285
    Conserved Domains (2) summary
    PRK10319
    Location:171 → 409
    PRK10319; N-acetylmuramoyl-L-alanine amidase AmiA
    pfam11741
    Location:39 → 142
    AMIN; AMIN domain
Nucleotide Protein
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