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argA N-acetylglutamate synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947289, updated on 26-Mar-2025

Summary

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Official Symbol
argA
Official Full Name
N-acetylglutamate synthase
Primary source
ECOCYC:EG10063
Locus tag
b2818
See related
ASAP:ABE-0009245
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
Arg1; Arg2; ECK2814
Summary
N-acetylglutamate synthase (ArgA) carries out the first steps in the superpathway of arginine biosynthesis and the pathway of ornithine biosynthesis. [More information is available at EcoCyc: EG10063].
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Genomic context

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Sequence:
NC_000913.3 (2949242..2950573)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-Met Neighboring gene N-acetylmuramoyl-L-alanine amidase C Neighboring gene exodeoxyribonuclease V subunit RecD Neighboring gene exodeoxyribonuclease V subunit RecB Neighboring gene protease 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. N-acetylglutamate synthase of Escherichia coli: purification, characterization, and molecular properties. Marvil DK, et al. J Biol Chem, 1977 May 25. PMID 16890
  2. Expression of the argA gene carried by a defective lambda bacteriophage of Escherichia coli. Leisinger T, et al. J Bacteriol, 1976 Mar. PMID 130376, Free PMC Article
  3. N-Acetylglutamate synthase of Escherichia coli regulation of synthesis and activity by arginine. Leisinger T, et al. J Biol Chem, 1975 Mar 10. PMID 1089665
  4. Isolation and characterization of mutants with a feedback resistant N-acetylglutamate synthase in Escherichia coli K 12. Eckhardt T, et al. Mol Gen Genet, 1975 Jun 19. PMID 1102931
  5. Identification of oligomerizing peptides. Dhiman A, et al. J Biol Chem, 2001 Jun 8. PMID 11274194

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Complete nucleotide sequence of the Escherichia coli argA gene.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables L-glutamate N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables glutamate N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within L-arginine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-arginine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within L-arginine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
N-acetylglutamate synthase
NP_417295.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2949242..2950573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417295.1 N-acetylglutamate synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417295.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2W6PET9
    Conserved Domains (1) summary
    PRK05279
    Location:1 → 442
    PRK05279; N-acetylglutamate synthase; Validated
Nucleotide Protein
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