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ptrA protease 3 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947284, updated on 26-Mar-2025

Summary

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Official Symbol
ptrA
Official Full Name
protease 3
Primary source
ECOCYC:EG10786
Locus tag
b2821
See related
ASAP:ABE-0009252
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2817; ptr
Summary
Protease III is a periplasmic protein that rapidly degrades small proteins and peptides in vitro . [More information is available at EcoCyc: EG10786].
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Genomic context

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Sequence:
NC_000913.3 (2955996..2958884, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene N-acetylglutamate synthase Neighboring gene exodeoxyribonuclease V subunit RecD Neighboring gene exodeoxyribonuclease V subunit RecB Neighboring gene exodeoxyribonuclease V subunit RecC Neighboring gene prepilin-type N-terminal cleavage/methylation domain-containing protein PpdC Neighboring gene DUF2509 domain-containing protein YgdB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Proteases in Escherichia coli. Goldberg AL, et al. Methods Enzymol, 1981. PMID 7043205
  2. Purification and characterization of protease III from Escherichia coli. Cheng YS, et al. J Biol Chem, 1979 Jun 10. PMID 374413
  3. Isolation and characterization of mutations in the structural gene for protease III (ptr). Cheng YS, et al. J Bacteriol, 1979 Oct. PMID 387716, Free PMC Article
  4. Extracellular release of protease III (ptr) by Escherichia coli K12. Díaz-Torres MR, et al. Can J Microbiol, 1991 Sep. PMID 1954583
  5. Construction and characterization of Escherichia coli strains deficient in multiple secreted proteases: protease III degrades high-molecular-weight substrates in vivo. Baneyx F, et al. J Bacteriol, 1991 Apr. PMID 2013581, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protease 3
NP_417298.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2955996..2958884 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417298.1 protease 3 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417298.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7S910
    Conserved Domains (1) summary
    PRK15101
    Location:1 → 960
    PRK15101; protease3; Provisional
Nucleotide Protein
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