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gcvA DNA-binding transcriptional dual regulator GcvA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947278, updated on 6-May-2021

Summary

Gene symbol
gcvA
Gene description
DNA-binding transcriptional dual regulator GcvA
Primary source
ASAP:ABE-0009202
Locus tag
b2808
See related
ECOCYC:EG11795
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2803
Summary
Glycine co-activator binds to GcvR and disrupts GcvA-GcvR interaction. [More information is available at EcoGene: EG11795]. "Glycine cleavage A," GcvA, is a repressor of the glycine cleavage enzyme system, which is a secondary pathway for production of C1 units . [More information is available at EcoCyc: EG11795].
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Genomic context

Sequence:
NC_000913.3 (2941650..2942567, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional activator FucR Neighboring gene 23S rRNA 2'-O-ribose C2498 methyltransferase Neighboring gene DUF423 domain-containing inner membrane protein YgdD Neighboring gene ncRNA Neighboring gene DUF903 domain-containing lipoprotein YgdI

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DNA-binding transcriptional dual regulator GcvA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2941650..2942567 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417288.1 DNA-binding transcriptional dual regulator GcvA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417288.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0A9F6
    Conserved Domains (1) summary
    PRK11139
    Location:1297
    PRK11139; DNA-binding transcriptional activator GcvA; Provisional
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