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glcA glycolate/lactate:H(+) symporter GlcA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947259, updated on 6-May-2021

Summary

Gene symbol
glcA
Gene description
glycolate/lactate:H(+) symporter GlcA
Primary source
ASAP:ABE-0009763
Locus tag
b2975
See related
ECOCYC:G7542
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2969; yghK
Summary
IT (Ion Transporter) superfamily (Prakash, 2003). [More information is available at EcoGene: EG12995]. YghK, also named GlcA, is a glycolate transporter that belongs to the Lactate Permease Family (LctP) , due to its strong sequence similarity with the L-lactate permease, LldP. [More information is available at EcoCyc: G7542].
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Genomic context

Sequence:
NC_000913.3 (3119597..3121279, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene prepilin peptidase Neighboring gene putative lipoprotein YghJ Neighboring gene malate synthase G Neighboring gene putative heme-binding protein GlcG

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables glycolate transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables lactate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lactate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables lactate transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables solute:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables solute:proton symporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within lactate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lactate transmembrane transport IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lactate transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
PubMed 

General protein information

Preferred Names
glycolate/lactate:H(+) symporter GlcA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3119597..3121279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417449.1 glycolate/lactate:H(+) symporter GlcA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417449.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q46839
    Conserved Domains (1) summary
    PRK09695
    Location:1560
    PRK09695; glycolate permease GlcA
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