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glcA glycolate/lactate:H(+) symporter GlcA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947259, updated on 19-Nov-2025
Official Symbol
glcA
Official Full Name
glycolate/lactate:H(+) symporter GlcA
Primary source
ECOCYC:G7542
Locus tag
b2975
See related
ASAP:ABE-0009763
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2969; yghK
Summary
IT (Ion Transporter) superfamily (Prakash, 2003). [More information is available at EcoGene: EG12995]. YghK, also named GlcA, is a glycolate transporter that belongs to the Lactate Permease Family (LctP) , due to its strong sequence similarity with the L-lactate permease, LldP. [More information is available at EcoCyc: G7542].
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Sequence:
NC_000913.3 (3119597..3121279, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene prepilin peptidase Neighboring gene putative mayloidogenic protein Neighboring gene malate synthase G Neighboring gene putative heme-binding protein GlcG

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Families of transmembrane sugar transport proteins. Saier MH Jr. Mol Microbiol, 2000 Feb. PMID 10692148
  2. Transport of L-Lactate, D-Lactate, and glycolate by the LldP and GlcA membrane carriers of Escherichia coli. Núñez MF, et al. Biochem Biophys Res Commun, 2002 Jan 18. PMID 11785976
  3. The gene yghK linked to the glc operon of Escherichia coli encodes a permease for glycolate that is structurally and functionally similar to L-lactate permease. Núñez MF, et al. Microbiology (Reading), 2001 Apr. PMID 11283302
  4. Domain structure and pore loops in the 2-hydroxycarboxylate transporter family. Lolkema JS. J Mol Microbiol Biotechnol, 2006. PMID 17114896
  5. Sequence and hydropathy profile analysis of two classes of secondary transporters. Lolkema JS, et al. Mol Membr Biol, 2005 May-Jun. PMID 16096261

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables glycolate transmembrane transporter activity EXP
Inferred from Experiment
more info
 PubMed 
enables lactate transmembrane transporter activity EXP
Inferred from Experiment
more info
 PubMed 
enables lactate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables solute:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables solute:proton symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycolate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lactate transmembrane transport EXP
Inferred from Experiment
more info
 PubMed 
involved_in lactate transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Preferred Names
glycolate/lactate:H(+) symporter GlcA

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3119597..3121279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417449.1 glycolate/lactate:H(+) symporter GlcA

    See identical proteins and their annotated locations for NP_417449.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A376M2J2, A0A8S7E8H4
    Conserved Domains (1) summary
    PRK09695
    Location:1 → 560
    PRK09695; glycolate permease GlcA
Nucleotide Protein
Heading Accession and Version

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