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gudD D-glucarate dehydratase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947258, updated on 19-Sep-2024

Summary

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Official Symbol
gudD
Official Full Name
D-glucarate dehydratase
Primary source
ECOCYC:G7445
Locus tag
b2787
See related
ASAP:ABE-0009134
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2781; ygcX
Summary
D-glucarate dehydratase catalyzes the dehydration of D-glucarate to 5-keto-4-deoxy-D-glucarate (KDG). [More information is available at EcoCyc: G7445].
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Genomic context

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Sequence:
NC_000913.3 (2918045..2919385, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 23S rRNA m(5)U1939 methyltransferase Neighboring gene sensor histidine kinase BarA Neighboring gene glucarate dehydratase-related protein Neighboring gene galactarate/D-glucarate transporter GudP

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bacterial conversion of D-glucarate to glycerate and pyruvate. BLUMENTHAL HJ, et al. Biochem Biophys Res Commun, 1963 May 3. PMID 13971911
  2. Evolution of enzymatic activities in the enolase superfamily: crystallographic and mutagenesis studies of the reaction catalyzed by D-glucarate dehydratase from Escherichia coli. Gulick AM, et al. Biochemistry, 2000 Apr 25. PMID 10769114
  3. Two genes affecting glucarate utilization in Escherichia coli K12. Roberton AM, et al. J Gen Microbiol, 1980 Apr. PMID 6999115
  4. Divergent evolution in the enolase superfamily: the interplay of mechanism and specificity. Gerlt JA, et al. Arch Biochem Biophys, 2005 Jan 1. PMID 15581566
  5. Evolution of enzymatic activities in the enolase superfamily: identification of the general acid catalyst in the active site of D-glucarate dehydratase from Escherichia coli. Gulick AM, et al. Biochemistry, 2001 Aug 28. PMID 11513584

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Evolution of enzymatic activities in the enolase superfamily: characterization of the (D)-glucarate/galactarate catabolic pathway in Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables glucarate dehydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucarate dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within D-glucarate catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in D-glucarate catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in D-glucarate catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glucarate catabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
D-glucarate dehydratase
NP_417267.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2918045..2919385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417267.1 D-glucarate dehydratase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417267.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376RDH0, A0A775YV54
    Conserved Domains (1) summary
    TIGR03247
    Location:5 → 446
    glucar-dehydr; glucarate dehydratase
Nucleotide Protein
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