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mazF endoribonuclease toxin MazF [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947252, updated on 6-May-2021

Summary

Gene symbol
mazF
Gene description
endoribonuclease toxin MazF
Primary source
ASAP:ABE-0009119
Locus tag
b2782
See related
ECOCYC:EG11249
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
chpA; chpAK; ECK2776
Summary
MazF is a sequence-specific (ACA) endoribonuclease, induced by amino acid starvation, but in a lon-dependent, ppGpp-independent fashion. [More information is available at EcoGene: EG11249]. MazF is a toxin that is counteracted by the MazE antitoxin . [More information is available at EcoCyc: EG11249].
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Genomic context

Sequence:
NC_000913.3 (2910756..2911091, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene CTP synthetase Neighboring gene nucleoside triphosphate pyrophosphohydrolase Neighboring gene antitoxin of the MazF-MazE toxin-antitoxin system MazE Neighboring gene GDP/GTP pyrophosphokinase Neighboring gene 23S rRNA m(5)U1939 methyltransferase

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables endoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables endoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
endoribonuclease toxin MazF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2910756..2911091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417262.1 endoribonuclease toxin MazF [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417262.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0AE70
    Conserved Domains (1) summary
    PRK09907
    Location:1111
    PRK09907; endoribonuclease MazF
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