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relA GDP/GTP pyrophosphokinase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947244, updated on 26-Mar-2025
Official Symbol
relA
Official Full Name
GDP/GTP pyrophosphokinase
Primary source
ECOCYC:EG10835
Locus tag
b2784
See related
ASAP:ABE-0009125
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2778; RC
Summary
RelA has two physically and functionally distinct domains, the N-terminal domain, amino acids 1 to 455, is responsible for (p)ppGpp synthesis, and the C-terminal domain, amino acids 456 to 744, is responsible for self regulation. [More information is available at EcoGene: EG10835].
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Sequence:
NC_000913.3 (2911417..2913651, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene nucleoside triphosphate pyrophosphohydrolase Neighboring gene endoribonuclease toxin MazF Neighboring gene antitoxin of the MazF-MazE toxin-antitoxin system MazE Neighboring gene 23S rRNA m(5)U1939 methyltransferase Neighboring gene sensor histidine kinase BarA

Genomic Sequence:
NC_000913.3

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTP diphosphokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP diphosphokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP diphosphokinase activity IEA
Inferred from Electronic Annotation
more info
 
enables guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
GDP/GTP pyrophosphokinase
NP_417264.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2911417..2913651 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417264.1 GDP/GTP pyrophosphokinase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417264.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7A6T5V0, A0A8T5Y9N7
    Conserved Domains (1) summary
    PRK10872
    Location:1743
    relA; (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional