U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

relA GDP/GTP pyrophosphokinase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947244, updated on 9-Mar-2022

Summary

Gene symbol
relA
Gene description
GDP/GTP pyrophosphokinase
Primary source
ASAP:ABE-0009125
Locus tag
b2784
See related
ECOCYC:EG10835
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2778; RC
Summary
RelA has two physically and functionally distinct domains, the N-terminal domain, amino acids 1 to 455, is responsible for (p)ppGpp synthesis, and the C-terminal domain, amino acids 456 to 744, is responsible for self regulation. [More information is available at EcoGene: EG10835].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Sequence:
NC_000913.3 (2911417..2913651, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene nucleoside triphosphate pyrophosphohydrolase Neighboring gene endoribonuclease toxin MazF Neighboring gene antitoxin of the MazF-MazE toxin-antitoxin system MazE Neighboring gene 23S rRNA m(5)U1939 methyltransferase Neighboring gene sensor histidine kinase BarA

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTP diphosphokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTP diphosphokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP diphosphokinase activity IEA
Inferred from Electronic Annotation
more info
 
enables guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
GDP/GTP pyrophosphokinase
NP_417264.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2911417..2913651 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417264.1 GDP/GTP pyrophosphokinase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417264.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0AG20
    Conserved Domains (1) summary
    PRK10872
    Location:1743
    relA; (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional