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cysI sulfite reductase, hemoprotein subunit [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947231, updated on 26-Mar-2025

Summary

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Official Symbol
cysI
Official Full Name
sulfite reductase, hemoprotein subunit
Primary source
ECOCYC:EG10190
Locus tag
b2763
See related
ASAP:ABE-0009061
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2758
Summary
Contains one siroheme and one 4-Fe-4S iron-sulfur center per chain. [More information is available at EcoCyc: EG10190].
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Genomic context

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Sequence:
NC_000913.3 (2888387..2890099, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene phosphoadenosine phosphosulfate reductase Neighboring gene sulfite reductase, flavoprotein subunit Neighboring gene 6-carboxy-5,6,7,8-tetrahydropterin synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structures of the siroheme- and Fe4S4-containing active center of sulfite reductase in different states of oxidation: heme activation via reduction-gated exogenous ligand exchange. Crane BR, et al. Biochemistry, 1997 Oct 7. PMID 9315848
  2. Mössbauer evidence for exchange-coupled siroheme and [4Fe-4S] prosthetic groups in Escherichia coli sulfite reductase. Studies of the reduced states and of a nitrite turnover complex. Christner JA, et al. J Biol Chem, 1983 Sep 25. PMID 6309833
  3. Proton NMR of Escherichia coli sulfite reductase: studies of the heme protein subunit with added ligands. Kaufman J, et al. Biochemistry, 1993 Aug 31. PMID 8395881
  4. Proton NMR of Escherichia coli sulfite reductase: the unligated hemeprotein subunit. Kaufman J, et al. Biochemistry, 1993 Mar 23. PMID 8457551
  5. Probing the catalytic mechanism of sulfite reductase by X-ray crystallography: structures of the Escherichia coli hemoprotein in complex with substrates, inhibitors, intermediates, and products. Crane BR, et al. Biochemistry, 1997 Oct 7. PMID 9315849

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Small-angle neutron scattering solution structures of NADPH-dependent sulfite reductase.
    Title: Small-angle neutron scattering solution structures of NADPH-dependent sulfite reductase.
  2. A model is proposed for the inhibition of growth in which the reduction of furfural by YqhD enzyme depletes NADPH sufficiently to limit the assimilation of sulfur into amino acids (cysteine and methionine) by CysIJ (sulfite reductase).
    Title: Furfural inhibits growth by limiting sulfur assimilation in ethanologenic Escherichia coli strain LY180.
  3. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables sulfite reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cysteine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cysteine biosynthetic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in hydrogen sulfide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sulfate assimilation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sulfate assimilation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sulfate assimilation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of sulfite reductase complex (NADPH) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of sulfite reductase complex (NADPH) IDA
Inferred from Direct Assay
more info
 PubMed 
part_of sulfite reductase complex (NADPH) IEA
Inferred from Electronic Annotation
more info
  
part_of sulfite reductase complex (NADPH) IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
sulfite reductase, hemoprotein subunit
NP_417243.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2888387..2890099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417243.1 sulfite reductase, hemoprotein subunit [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417243.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A485JA78
    Conserved Domains (1) summary
    PRK13504
    Location:5 → 569
    PRK13504; NADPH-dependent assimilatory sulfite reductase hemoprotein subunit
Nucleotide Protein
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