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cysH phosphoadenosine phosphosulfate reductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947230, updated on 30-Jul-2025
Official Symbol
cysH
Official Full Name
phosphoadenosine phosphosulfate reductase
Primary source
ECOCYC:EG10189
Locus tag
b2762
See related
ASAP:ABE-0009057
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2757
Summary
PAPS reductase is composed of two identical subunits of 28 kDa. [More information is available at EcoCyc: EG10189].
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Sequence:
NC_000913.3 (2887578..2888312, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene CRISPR-associated endonuclease/helicase Cas3 Neighboring gene ncRNA Neighboring gene sulfite reductase, hemoprotein subunit Neighboring gene sulfite reductase, flavoprotein subunit

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. PAPS-reductase of Escherichia coli. Correlating the N-terminal amino acid sequence with the DNA of gene cys H. Krone FA, et al. FEBS Lett, 1990 Jan 15. PMID 2404794
  2. Pharmacokinetic and pharmacodynamic effects of high-dose continuous intravenous verapamil infusion: clinical experience in the intensive care unit. De Cicco M, et al. Crit Care Med, 1999 Feb. PMID 10075058
  3. 3'-Phosphoadenosine-5'-phosphosulfate reductase in complex with thioredoxin: a structural snapshot in the catalytic cycle. Chartron J, et al. Biochemistry, 2007 Apr 3. PMID 17352498, Free PMC Article
  4. New thioredoxins and glutaredoxins as electron donors of 3'-phosphoadenylylsulfate reductase. Lillig CH, et al. J Biol Chem, 1999 Mar 19. PMID 10075658
  5. Characterisation of the gene cysH and of its product phospho-adenylylsulphate reductase from Escherichia coli. Krone FA, et al. Mol Gen Genet, 1991 Feb. PMID 2005873

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inactivation of the cysH gene results in increased surface adhesion and cell aggregation by activating the expression of the curli-encoding csgBAC operon via phosphoadenosine 59-phosphosulfate accumulation.
    Title: Sulfate assimilation pathway intermediate phosphoadenosine 59-phosphosulfate acts as a signal molecule affecting production of curli fibres in Escherichia coli.
  2. N-terminus verified by Edman degradation on mature peptide
    Title: PAPS-reductase of Escherichia coli. Correlating the N-terminal amino acid sequence with the DNA of gene cys H.
  3. the structure of PAPS reductase in complex with thioredoxin highlights the large structural rearrangement required to accomplish sulfonucleotide reduction and suggests a role for Trx in catalysis beyond the paradigm of disulfide reduction.
    Title: 3'-Phosphoadenosine-5'-phosphosulfate reductase in complex with thioredoxin: a structural snapshot in the catalytic cycle.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoadenylyl-sulfate reductase (thioredoxin) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoadenylyl-sulfate reductase (thioredoxin) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoadenylyl-sulfate reductase (thioredoxin) activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoadenylyl-sulfate reductase (thioredoxin) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in hydrogen sulfide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sulfur compound metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
phosphoadenosine phosphosulfate reductase
NP_417242.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2887578..2888312 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417242.1 phosphoadenosine phosphosulfate reductase

    See identical proteins and their annotated locations for NP_417242.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5B9ASU8
    Conserved Domains (1) summary
    PRK02090
    Location:6 → 244
    PRK02090; phosphoadenylyl-sulfate reductase
Nucleotide Protein
Heading Accession and Version

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