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casE pre-CRISPR RNA endonuclease [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947226, updated on 6-May-2021

Summary

Gene symbol
casE
Gene description
pre-CRISPR RNA endonuclease
Primary source
ASAP:ABE-0009042
Locus tag
b2756
See related
ECOCYC:G7426
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cas6e; cse3; ECK2751; ygcH
Summary
The Cascade antiviral complex is comprised of CasABCDE and short CRISP RNAs (crRNAs) and requires the predicted helicase YgcB(Cas3) for activity (Brouns , 2008). [More information is available at EcoGene: EG13115]. CasE is the only Cascade subunit that is necessary and sufficient for cleavage of pre-CRISPR RNA (crRNA). [More information is available at EcoCyc: G7426].
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Genomic context

Sequence:
NC_000913.3 (2879788..2880387, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene CRISPR-associated endoribonuclease Cas2 Neighboring gene multifunctional nuclease Cas1 Neighboring gene type I-E CRISPR system Cascade subunit CasD Neighboring gene type I-E CRISPR system Cascade subunit CasC Neighboring gene type I-E CRISPR system Cascade subunit CasB Neighboring gene type I-E CRISPR system Cascade subunit CasA

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables endoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
pre-CRISPR RNA endonuclease

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2879788..2880387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417236.1 pre-CRISPR RNA endonuclease [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417236.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q46897
    Conserved Domains (1) summary
    TIGR01907
    Location:1199
    casE_Cse3; CRISPR-associated protein Cas6/Cse3/CasE, subtype I-E/ECOLI
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