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casD type I-E CRISPR system Cascade subunit CasD [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947225, updated on 30-Jul-2025
Official Symbol
casD
Official Full Name
type I-E CRISPR system Cascade subunit CasD
Primary source
ECOCYC:G7427
Locus tag
b2757
See related
ASAP:ABE-0009044
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cas5e; ECK2752; ygcI
Summary
The Cascade antiviral complex is comprised of CasABCDE and short CRISP RNAs (crRNAs) and requires the predicted helicase YgcB(Cas3) for activity (Brouns , 2008). [More information is available at EcoGene: EG13116]. CasD: [More information is available at EcoCyc: G7427].
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Sequence:
NC_000913.3 (2880374..2881048, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene CRISPR-associated endoribonuclease Cas2 Neighboring gene multifunctional nuclease Cas1 Neighboring gene pre-CRISPR RNA endonuclease Neighboring gene type I-E CRISPR system Cascade subunit CasC Neighboring gene type I-E CRISPR system Cascade subunit CasB Neighboring gene type I-E CRISPR system Cascade subunit CasA

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structural biology. Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli. Jackson RN, et al. Science, 2014 Sep 19. PMID 25103409, Free PMC Article
  2. Molecular biology. Secret weapon. Young RF 3rd. Science, 2008 Aug 15. PMID 18703730, Free PMC Article
  3. Structural biology. Crystal structure of a CRISPR RNA-guided surveillance complex bound to a ssDNA target. Mulepati S, et al. Science, 2014 Sep 19. PMID 25123481, Free PMC Article
  4. Small CRISPR RNAs guide antiviral defense in prokaryotes. Brouns SJ, et al. Science, 2008 Aug 15. PMID 18703739, Free PMC Article
  5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA/RNA hybrid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in CRISPR-cas system IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within defense response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in maintenance of CRISPR repeat elements IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
type I-E CRISPR system Cascade subunit CasD

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2880374..2881048 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417237.2 type I-E CRISPR system Cascade subunit CasD

    See identical proteins and their annotated locations for NP_417237.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0ABC8DWF1
    Conserved Domains (1) summary
    TIGR01868
    Location:3 → 216
    casD_Cas5e; CRISPR-associated protein Cas5/CasD, subtype I-E/ECOLI
Nucleotide Protein
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