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casB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947223, updated on 11-Sep-2024

Summary

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Official Symbol
casB
Primary source
ECOCYC:G7429
Locus tag
b2759
See related
ASAP:ABE-0009048
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cse2; ECK2754; ygcK
Summary
The Cascade antiviral complex is comprised of CasABCDE and short CRISP RNAs (crRNAs) and requires the predicted helicase YgcB(Cas3) for activity (Brouns , 2008). [More information is available at EcoGene: EG13118]. An insertion mutant in casB/ygcK shows lower transposition of IS903 . [More information is available at EcoCyc: G7429].
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Genomic context

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Sequence:
NC_000913.3 (2882155..2882637, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pre-CRISPR RNA endonuclease Neighboring gene type I-E CRISPR system Cascade subunit CasD Neighboring gene type I-E CRISPR system Cascade subunit CasC Neighboring gene type I-E CRISPR system Cascade subunit CasA Neighboring gene CRISPR-associated endonuclease/helicase Cas3 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nucleic acid binding surface and dimer interface revealed by CRISPR-associated CasB protein structures. Nam KH, et al. FEBS Lett, 2012 Nov 16. PMID 23079036, Free PMC Article
  2. Structural biology. Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli. Jackson RN, et al. Science, 2014 Sep 19. PMID 25103409, Free PMC Article
  3. Molecular biology. Secret weapon. Young RF 3rd. Science, 2008 Aug 15. PMID 18703730, Free PMC Article
  4. Structural biology. Crystal structure of a CRISPR RNA-guided surveillance complex bound to a ssDNA target. Mulepati S, et al. Science, 2014 Sep 19. PMID 25123481, Free PMC Article
  5. Transposition is modulated by a diverse set of host factors in Escherichia coli and is stimulated by nutritional stress. Twiss E, et al. Mol Microbiol, 2005 Sep. PMID 16135227

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in CRISPR-cas system IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
type I-E CRISPR system Cascade subunit CasB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2882155..2882637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417239.1 type I-E CRISPR system Cascade subunit CasB [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417239.1

    Status: PROVISIONAL

    Conserved Domains (1) summary
    cd09670
    Location:9 → 155
    Cse2_I-E; CRISPR/Cas system-associated protein Cse2
Nucleotide Protein
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