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umpG broad specificity 5'(3')-nucleotidase and polyphosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947211, updated on 25-Jun-2025
Official Symbol
umpG
Official Full Name
broad specificity 5'(3')-nucleotidase and polyphosphatase
Primary source
ECOCYC:EG11817
Locus tag
b2744
See related
ASAP:ABE-0009008
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2739; surE; ygbC
Summary
A surE mutation is a specific suppressor of pcm stationary phase survival defects. [More information is available at EcoGene: EG11817]. SurE is a phosphatase with broad substrate specificity. [More information is available at EcoCyc: EG11817].
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Sequence:
NC_000913.3 (2869513..2870274, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene RNA polymerase sigma factor RpoS Neighboring gene murein hydrolase activator NlpD Neighboring gene protein-L-isoaspartate O-methyltransferase Neighboring gene tRNA pseudouridine(13) synthase Neighboring gene 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Neighboring gene 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Crystal structure and functional analysis of the SurE protein identify a novel phosphatase family. Lee JY, et al. Nat Struct Biol, 2001 Sep. PMID 11524683
  2. Genetic architecture of thermal adaptation in Escherichia coli. Riehle MM, et al. Proc Natl Acad Sci U S A, 2001 Jan 16. PMID 11149947, Free PMC Article
  3. Growth-phase-dependent transcriptional regulation of the pcm and surE genes required for stationary-phase survival of Escherichia coli. Li C, et al. Microbiology (Reading), 1997 Nov. PMID 9387229
  4. Pyrimidine homeostasis is accomplished by directed overflow metabolism. Reaves ML, et al. Nature, 2013 Aug 8. PMID 23903661, Free PMC Article
  5. Mutations in the Escherichia coli surE gene increase isoaspartyl accumulation in a strain lacking the pcm repair methyltransferase but suppress stress-survival phenotypes. Visick JE, et al. FEMS Microbiol Lett, 1998 Oct 1. PMID 9785447

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. identified the presence of nucleotidase activity in three uncharacterized E. coli proteins, SurE, YfbR, and YjjG, that belong to different enzyme superfamilies
    Title: General enzymatic screens identify three new nucleotidases in Escherichia coli. Biochemical characterization of SurE, YfbR, and YjjG.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3'-nucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5'-nucleotidase activity IEA
Inferred from Electronic Annotation
more info
  
enables exopolyphosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables manganese ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within UMP catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Preferred Names
broad specificity 5'(3')-nucleotidase and polyphosphatase
NP_417224.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2869513..2870274 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417224.1 broad specificity 5'(3')-nucleotidase and polyphosphatase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417224.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7L7EG62, A0A8S7R707
    Conserved Domains (1) summary
    PRK00346
    Location:1 → 245
    surE; 5'(3')-nucleotidase/polyphosphatase; Provisional
Nucleotide Protein
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