U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

umpG broad specificity 5'(3')-nucleotidase and polyphosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947211, updated on 8-Dec-2022

Summary

Go to the top of the page Help
Gene symbol
umpG
Gene description
broad specificity 5'(3')-nucleotidase and polyphosphatase
Primary source
ASAP:ABE-0009008
Locus tag
b2744
See related
ECOCYC:EG11817
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2739; surE; ygbC
Summary
A surE mutation is a specific suppressor of pcm stationary phase survival defects. [More information is available at EcoGene: EG11817]. SurE is a phosphatase with broad substrate specificity. [More information is available at EcoCyc: EG11817].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (2869513..2870274, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene RNA polymerase sigma factor RpoS Neighboring gene murein hydrolase activator NlpD Neighboring gene protein-L-isoaspartate O-methyltransferase Neighboring gene tRNA pseudouridine(13) synthase Neighboring gene 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Neighboring gene 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Crystal structure and functional analysis of the SurE protein identify a novel phosphatase family. Lee JY, et al. Nat Struct Biol, 2001 Sep. PMID 11524683
  2. Genetic architecture of thermal adaptation in Escherichia coli. Riehle MM, et al. Proc Natl Acad Sci U S A, 2001 Jan 16. PMID 11149947, Free PMC Article
  3. Mutations in the Escherichia coli surE gene increase isoaspartyl accumulation in a strain lacking the pcm repair methyltransferase but suppress stress-survival phenotypes. Visick JE, et al. FEMS Microbiol Lett, 1998 Oct 1. PMID 9785447
  4. Growth-phase-dependent transcriptional regulation of the pcm and surE genes required for stationary-phase survival of Escherichia coli. Li C, et al. Microbiology (Reading), 1997 Nov. PMID 9387229
  5. Pyrimidine homeostasis is accomplished by directed overflow metabolism. Reaves ML, et al. Nature, 2013 Aug 8. PMID 23903661, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. identified the presence of nucleotidase activity in three uncharacterized E. coli proteins, SurE, YfbR, and YjjG, that belong to different enzyme superfamilies
    Title: General enzymatic screens identify three new nucleotidases in Escherichia coli. Biochemical characterization of SurE, YfbR, and YjjG.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables 3'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables 3'-nucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables 5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables exopolyphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables exopolyphosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables manganese ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in UMP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within UMP catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
broad specificity 5'(3')-nucleotidase and polyphosphatase
NP_417224.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2869513..2870274 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417224.1 broad specificity 5'(3')-nucleotidase and polyphosphatase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417224.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0A840
    Conserved Domains (1) summary
    PRK00346
    Location:1 → 245
    surE; 5'(3')-nucleotidase/polyphosphatase; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials