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uvrC UvrABC excision nuclease subunit C [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947203, updated on 10-Oct-2024

Summary

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Official Symbol
uvrC
Official Full Name
UvrABC excision nuclease subunit C
Primary source
ECOCYC:EG11063
Locus tag
b1913
See related
ASAP:ABE-0006370
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1912
Summary
UvrC is one of three (along with UvrA and UvrB) enzyme components participating in the nucleotide excision repair (NER) process. [More information is available at EcoCyc: EG11063].
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Genomic context

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Sequence:
NC_000913.3 (1992874..1994706, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-Gly Neighboring gene CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Neighboring gene DNA-binding transcriptional activator UvrY Neighboring gene protein YecU Neighboring gene DUF2594 domain-containing protein YecF Neighboring gene DNA-binding transcriptional dual regulator SdiA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interrogating the substrate specificity landscape of UvrC reveals novel insights into its non-canonical function. Thakur M, et al. Biophys J, 2022 Aug 16. PMID 35810330, Free PMC Article
  2. The C-terminal region of Escherichia coli UvrC contributes to the flexibility of the UvrABC nucleotide excision repair system. Verhoeven EE, et al. Nucleic Acids Res, 2002 Jun 1. PMID 12034838, Free PMC Article
  3. Sequence-dependent interactions of two forms of UvrC with DNA helix-stabilizing CC-1065-N3-adenine adducts. Nazimiec M, et al. Biochemistry, 2001 Sep 18. PMID 11551204
  4. Two forms of UvrC protein with different double-stranded DNA binding affinities. Tang Ms, et al. J Biol Chem, 2001 Feb 9. PMID 11056168
  5. The C-terminal region of the Escherichia coli UvrC protein, which is homologous to the C-terminal region of the human ERCC1 protein, is involved in DNA binding and 5'-incision. Moolenaar GF, et al. Nucleic Acids Res, 1998 Jan 15. PMID 9421501, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interrogating the substrate specificity landscape of UvrC reveals novel insights into its non-canonical function.
    Title: Interrogating the substrate specificity landscape of UvrC reveals novel insights into its non-canonical function.
  2. Recruitment of UvrBC complexes to UV-induced damage in the absence of UvrA increases bacterial survival.
    Title: Recruitment of UvrBC complexes to UV-induced damage in the absence of UvrA increases cell survival.
  3. N-terminus verified by Edman degradation on mature peptide
    Title: Two forms of UvrC protein with different double-stranded DNA binding affinities.
  4. In solution, two UvrB subunits bind to UvrA, most likely as part of a UvrA2B2 complex. The UvrA-induced dimerization of the C-terminal domain 4 regions of UvrB serves to shield these domains from premature UvrC binding.
    Title: Dynamics of the UvrABC nucleotide excision repair proteins analyzed by fluorescence resonance energy transfer.
  5. we examined the interaction of UvrABC with a DNA substrate containing a single G[8,5-Me]T cross-link and compared it with T[6,4]T (the 6-4 pyrimidine-pyrimidone photoproduct) and the C8 guanine adduct of N-acetyl-2-aminofluorene (AAF)
    Title: Recognition and incision of gamma-radiation-induced cross-linked guanine-thymine tandem lesion G[8,5-Me]T by UvrABC nuclease.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables excinuclease ABC activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in SOS response IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide-excision repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to radiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of excinuclease repair complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of excinuclease repair complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of excinuclease repair complex IEA
Inferred from Electronic Annotation
more info
  
part_of excinuclease repair complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
UvrABC excision nuclease subunit C

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1992874..1994706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416423.4 UvrABC excision nuclease subunit C [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416423.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376M8J4, A0A5B9AHU8, A0A7D7KIK0, A0A895NVN1, A0A8H9XPE3, A0AAQ2LPG9
    Conserved Domains (1) summary
    PRK00558
    Location:8 → 610
    uvrC; excinuclease ABC subunit UvrC
Nucleotide Protein
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