hypA hydrogenase 3 nickel incorporation protein HypA [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Gene symbol: hypA
Gene description: hydrogenase 3 nickel incorporation protein HypA
Primary source: ASAP:ABE-0008958
Locus tag: b2726
See related: ECOCYC:EG10483
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK2721
Summary: hypA mutants have increased Hydrogenase 2 activity but similar amounts of HypA protein. hypA defect suppressed by expression of hypB-E under foreign promoter, indicating a regulatory or partially redundant function. [More information is available at EcoGene: EG10483]. HypA and its homolog, HybF, are involved in the maturation of hydrogenase isozymes. [More information is available at EcoCyc: EG10483].
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NC_000913.3 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nickel cation binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables nickel cation binding	IDA Inferred from Direct Assay more info	PubMed
enables nickel cation binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular protein modification process	IEA Inferred from Electronic Annotation more info
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within protein maturation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein maturation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

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