U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

hypA hydrogenase 3 Ni(2(+)) incorporation protein HypA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947195, updated on 17-Jul-2025
Official Symbol
hypA
Official Full Name
hydrogenase 3 Ni(2(+)) incorporation protein HypA
Primary source
ECOCYC:EG10483
Locus tag
b2726
See related
ASAP:ABE-0008958
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2721
Summary
hypA mutants have increased Hydrogenase 2 activity but similar amounts of HypA protein. hypA defect suppressed by expression of hypB-E under foreign promoter, indicating a regulatory or partially redundant function. [More information is available at EcoGene: EG10483]. HypA and its homolog, HybF, are involved in the maturation of hydrogenase isozymes. [More information is available at EcoCyc: EG10483].
NEW
Try the new Gene table
Try the new Transcript table
Sequence:
NC_000913.3 (2850647..2850997)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene hydrogenase 3 membrane subunit HycC Neighboring gene hydrogenase 3 Neighboring gene regulator of the transcriptional regulator FhlA Neighboring gene hydrogenase isoenzymes Ni(2(+)) incorporation protein HypB Neighboring gene hydrogenase maturation factor HypC Neighboring gene Fe-(CN)2CO cofactor assembly scaffold protein HypD Neighboring gene carbamoyl dehydratase HypE

Genomic Sequence:
NC_000913.3
Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metallochaperone activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables nickel cation binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nickel cation binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein-containing complex assembly NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of GTPase complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of metallochaperone complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
hydrogenase 3 Ni(2(+)) incorporation protein HypA

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2850647..2850997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417206.1 hydrogenase 3 Ni(2(+)) incorporation protein HypA

    See identical proteins and their annotated locations for NP_417206.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0H3ELG5, A0AAJ3NW56, B1LQ46
    Conserved Domains (1) summary
    PRK03681
    Location:1114
    hypA; hydrogenase/urease nickel incorporation protein HypA