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hycG hydrogenase 3 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947191, updated on 4-Feb-2026
Official Symbol
hycG
Official Full Name
hydrogenase 3
Primary source
ECOCYC:EG10480
Locus tag
b2719
See related
ASAP:ABE-0008936
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2714; hevG
Summary
FhlA regulon. [More information is available at EcoGene: EG10480]. HycG has similarity to small subunits of hydrogenases and resembles one of the subunits of NADH:ubiquinone oxidoreductase of the respiratory chain . [More information is available at EcoCyc: EG10480].
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Sequence:
NC_000913.3 (2843443..2844210, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene cryptic 6-phospho-beta-glucosidase AscB Neighboring gene hydrogenase 3 maturation protease Neighboring gene formate hydrogenlyase assembly protein Neighboring gene hydrogenase 3 Neighboring gene hydrogenase 3 large subunit Neighboring gene hydrogenase 3 membrane subunit HycD

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Differential expression of hydrogenase isoenzymes in Escherichia coli K-12: evidence for a third isoenzyme. Sawers RG, et al. J Bacteriol, 1985 Dec. PMID 3905769, Free PMC Article
  2. Microbial reduction of technetium by Escherichia coli and Desulfovibrio desulfuricans: enhancement via the use of high-activity strains and effect of process parameters. Lloyd JR, et al. Biotechnol Bioeng, 1999. PMID 10567070
  3. Reduction and removal of heptavalent technetium from solution by Escherichia coli. Lloyd JR, et al. J Bacteriol, 1997 Mar. PMID 9068649, Free PMC Article
  4. Studying protein complexes by the yeast two-hybrid system. Rajagopala SV, et al. Methods, 2012 Dec. PMID 22841565, Free PMC Article
  5. Regulated expression in vitro of genes coding for formate hydrogenlyase components of Escherichia coli. Hopper S, et al. J Biol Chem, 1994 Jul 29. PMID 8034728

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables NADH dehydrogenase (ubiquinone) activity IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables quinone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anaerobic electron transport chain IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anaerobic electron transport chain IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in anaerobic respiration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in formate oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in formate oxidation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glucose catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of formate dehydrogenase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
hydrogenase 3
NP_417199.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2843443..2844210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417199.1 hydrogenase 3 [Fe-S] protein HycG

    See identical proteins and their annotated locations for NP_417199.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S7ECC1
    Conserved Domains (1) summary
    COG3260
    Location:30 → 177
    HycG; Ni,Fe-hydrogenase III small subunit [Energy production and conversion]
Nucleotide Protein
Heading Accession and Version

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