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mltB membrane-bound lytic murein transglycosylase B [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947184, updated on 6-Jul-2026
Official Symbol
mltB
Official Full Name
membrane-bound lytic murein transglycosylase B
Primary source
ECOCYC:G7410
Locus tag
b2701
See related
ASAP:ABE-0008885
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2696; slt
Summary
MltB cleaves the glycosidic bonds between the N-acetylmuramic acid and N-acetylglucosamine residues in murein. [More information is available at EcoGene: EG12699]. MltB is one of six (along with MltA, MltC, MltD, EmtA, and Slt70) major lytic endotransglycosylases expressed in Escherichia coli. [More information is available at EcoCyc: G7410].
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Sequence:
NC_000913.3 (2824491..2825576, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA recombination/repair protein RecA Neighboring gene NMN aminohydrolase Neighboring gene sorbitol-specific PTS enzyme IIC2 component Neighboring gene sorbitol-specific PTS enzyme IIBC1 component Neighboring gene sorbitol-specific PTS enzyme IIA component

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Lytic transglycosylase MltB of Escherichia coli and its role in recycling of peptidoglycan strands of bacterial cell wall. Suvorov M, et al. J Am Chem Soc, 2008 Sep 10. PMID 18700763, Free PMC Article
  2. Cloning and controlled overexpression of the gene encoding the 35 kDa soluble lytic transglycosylase from Escherichia coli. Dijkstra AJ, et al. FEBS Lett, 1995 Jun 12. PMID 7789526
  3. Accelerated X-ray structure elucidation of a 36 kDa muramidase/transglycosylase using wARP. Van Asselt EJ, et al. Acta Crystallogr D Biol Crystallogr, 1998 Jan 1. PMID 9761817
  4. Crystal structure of Escherichia coli lytic transglycosylase Slt35 reveals a lysozyme-like catalytic domain with an EF-hand. van Asselt EJ, et al. Structure, 1999 Oct 15. PMID 10545329
  5. Binding of calcium in the EF-hand of Escherichia coli lytic transglycosylase Slt35 is important for stability. van Asselt EJ, et al. FEBS Lett, 1999 Sep 24. PMID 10570954

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lytic endotransglycosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidoglycan lytic transglycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidoglycan lytic transglycosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sodium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptidoglycan catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within peptidoglycan catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within peptidoglycan catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in outer membrane-bounded periplasmic space TAS
Traceable Author Statement
more info
 PubMed 
Preferred Names
membrane-bound lytic murein transglycosylase B

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2824491..2825576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417181.1 membrane-bound lytic murein transglycosylase B

    See identical proteins and their annotated locations for NP_417181.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0H2Z268
    Conserved Domains (1) summary
    PRK10760
    Location:1 → 361
    PRK10760; murein hydrolase B; Provisional
Nucleotide Protein
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