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fhlA DNA-binding transcriptional activator FhlA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947181, updated on 19-Sep-2024

Summary

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Official Symbol
fhlA
Official Full Name
DNA-binding transcriptional activator FhlA
Primary source
ECOCYC:EG10301
Locus tag
b2731
See related
ASAP:ABE-0008971
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2726; fhl
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Genomic context

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Sequence:
NC_000913.3 (2854338..2856416)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene hydrogenase isoenzymes nickel incorporation protein HypB Neighboring gene hydrogenase maturation factor HypC Neighboring gene Fe-(CN)2CO cofactor assembly scaffold protein HypD Neighboring gene carbamoyl dehydratase HypE Neighboring gene protein YgbA Neighboring gene DNA mismatch repair protein MutS

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Exploring the directionality of Escherichia coli formate hydrogenlyase: a membrane-bound enzyme capable of fixing carbon dioxide to organic acid. Pinske C, et al. Microbiologyopen, 2016 Oct. PMID 27139710, Free PMC Article
  2. Protein engineering of the transcriptional activator FhlA To enhance hydrogen production in Escherichia coli. Sanchez-Torres V, et al. Appl Environ Microbiol, 2009 Sep. PMID 19581479, Free PMC Article
  3. Sodium regulation of GAF domain function. Cann MJ. Biochem Soc Trans, 2007 Nov. PMID 17956270
  4. Enhanced hydrogen production from glucose by metabolically engineered Escherichia coli. Maeda T, et al. Appl Microbiol Biotechnol, 2007 Dec. PMID 17938909
  5. Formate and its role in hydrogen production in Escherichia coli. Sawers RG. Biochem Soc Trans, 2005 Feb. PMID 15667260

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The physiological role of FHL is to oxidize formate with the concomitant production of molecular hydrogen. The unambiguous demonstration that FHL can operate in the fi xing of CO2 to formate both in vivo and in vitro is an important fi nding.
    Title: Exploring the directionality of Escherichia coli formate hydrogenlyase: a membrane-bound enzyme capable of fixing carbon dioxide to organic acid.
  2. Hfq binding site in the fhlA mRNA leader region facilitates the OxyS-fhlA interaction.
    Title: An upstream Hfq binding site in the fhlA mRNA leader region facilitates the OxyS-fhlA interaction.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding transcriptional activator FhlA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2854338..2856416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417211.1 DNA-binding transcriptional activator FhlA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417211.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6M9X4D8, A0A895NVT2
    Conserved Domains (1) summary
    PRK15429
    Location:4 → 689
    PRK15429; formate hydrogenlyase transcriptional activator FlhA
Nucleotide Protein
Heading Accession and Version

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