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nrdE ribonucleoside-diphosphate reductase 2 subunit alpha [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947155, updated on 9-Mar-2022

Summary

Gene symbol
nrdE
Gene description
ribonucleoside-diphosphate reductase 2 subunit alpha
Primary source
ASAP:ABE-0008806
Locus tag
b2675
See related
ECOCYC:EG20257
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2669
Summary
nrdE is a nonessential gene. [More information is available at EcoGene: EG20257]. Expression of the nrdHIEF operon is increased by hydroxyurea and oxidative stress . [More information is available at EcoCyc: EG20257].
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Genomic context

Sequence:
NC_000913.3 (2801348..2803492)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF883 domain-containing protein YgaM Neighboring gene glutaredoxin-like protein NrdH Neighboring gene dimanganese-tyrosyl radical cofactor maintenance flavodoxin NrdI Neighboring gene ribonucleoside-diphosphate reductase 2 subunit beta Neighboring gene glycine betaine ABC transporter ATP binding subunit ProV Neighboring gene glycine betaine ABC transporter membrane subunit ProW

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IEA
Inferred from Electronic Annotation
more info
 
contributes_to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IGI
Inferred from Genetic Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in deoxyribonucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within deoxyribonucleotide biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nucleobase-containing small molecule interconversion IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISA
Inferred from Sequence Alignment
more info
PubMed 
part_of ribonucleoside-diphosphate reductase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ribonucleoside-diphosphate reductase complex IGI
Inferred from Genetic Interaction
more info
PubMed 

General protein information

Preferred Names
ribonucleoside-diphosphate reductase 2 subunit alpha
NP_417161.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2801348..2803492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417161.1 ribonucleoside-diphosphate reductase 2 subunit alpha [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417161.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P39452
    Conserved Domains (1) summary
    PRK08188
    Location:1714
    PRK08188; ribonucleotide-diphosphate reductase subunit alpha; Validated