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proV glycine betaine ABC transporter ATP binding subunit ProV [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947148, updated on 30-Jul-2025
Official Symbol
proV
Official Full Name
glycine betaine ABC transporter ATP binding subunit ProV
Primary source
ECOCYC:EG10771
Locus tag
b2677
See related
ASAP:ABE-0008814
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2671; osrA; proU
Summary
ProVWX, the high-affinity transport system for the osmoprotectant glycine betaine, is a member of the ATP-Binding Cassette (ABC) Superfamily of transporters . [More information is available at EcoCyc: EG10771].
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Sequence:
NC_000913.3 (2804815..2806017)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene dimanganese-tyrosyl radical cofactor maintenance flavodoxin NrdI Neighboring gene ribonucleoside-diphosphate reductase 2 subunit alpha Neighboring gene ribonucleoside-diphosphate reductase 2 subunit beta Neighboring gene glycine betaine ABC transporter membrane subunit ProW Neighboring gene glycine betaine ABC transporter periplasmic binding protein ProX Neighboring gene pseudo

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Selection of mutations that alter the osmotic control of transcription of the Salmonella typhimurium proU operon. Druger-Liotta J, et al. J Bacteriol, 1987 Jun. PMID 3294791, Free PMC Article
  2. A novel, non-invasive promoter probe vector: cloning of the osmoregulated proU promoter of Escherichia coli K12. Park SF, et al. Mol Microbiol, 1989 Aug. PMID 2691837
  3. A sensor for intracellular ionic strength. Biemans-Oldehinkel E, et al. Proc Natl Acad Sci U S A, 2006 Jul 11. PMID 16815971, Free PMC Article
  4. A transcriptional silencer downstream of the promoter in the osmotically controlled proU operon of Salmonella typhimurium. Overdier DG, et al. Proc Natl Acad Sci U S A, 1992 Apr 1. PMID 1557423, Free PMC Article
  5. Osmotic signal transduction to proU is independent of DNA supercoiling in Escherichia coli. Ramirez RM, et al. J Bacteriol, 1991 Jan. PMID 1670937, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The proU mRNA is processed by RNase III and this processing is osmoregulated.
    Title: RNase III initiates rapid degradation of proU mRNA upon hypo-osmotic stress in Escherichia coli.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISM
Inferred from Sequence Model
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables amine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables osmosensor activity ISM
Inferred from Sequence Model
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in amine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to osmotic stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to osmotic stress IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycine betaine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycine betaine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycine betaine transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycine betaine transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in glycine import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within hyperosmotic response IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within hyperosmotic response IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of ATP-binding cassette (ABC) transporter complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ATP-binding cassette (ABC) transporter complex ISM
Inferred from Sequence Model
more info
 PubMed 
part_of ProVWX complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
glycine betaine ABC transporter ATP binding subunit ProV
NP_417163.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2804815..2806017
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417163.1 glycine betaine ABC transporter ATP binding subunit ProV

    See identical proteins and their annotated locations for NP_417163.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    W1WDS6
    Conserved Domains (1) summary
    PRK10070
    Location:1 → 400
    PRK10070; proline/glycine betaine ABC transporter ATP-binding protein ProV
Nucleotide Protein
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