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proW glycine betaine ABC transporter membrane subunit ProW [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947145, updated on 3-Dec-2024

Summary

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Official Symbol
proW
Official Full Name
glycine betaine ABC transporter membrane subunit ProW
Primary source
ECOCYC:EG10772
Locus tag
b2678
See related
ASAP:ABE-0008816
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2672; osrA; proU
Summary
ProVWX, the high-affinity transport system for the osmoprotectant glycine betaine, is a member of the ATP-Binding Cassette (ABC) Superfamily of transporters . [More information is available at EcoCyc: EG10772].
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Genomic context

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Sequence:
NC_000913.3 (2806010..2807074)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene dimanganese-tyrosyl radical cofactor maintenance flavodoxin NrdI Neighboring gene ribonucleoside-diphosphate reductase 2 subunit alpha Neighboring gene ribonucleoside-diphosphate reductase 2 subunit beta Neighboring gene glycine betaine ABC transporter ATP binding subunit ProV Neighboring gene glycine betaine ABC transporter periplasmic binding protein ProX Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Use of phoA and lacZ fusions to study the membrane topology of ProW, a component of the osmoregulated ProU transport system of Escherichia coli. Haardt M, et al. J Bacteriol, 1996 Sep. PMID 8808924, Free PMC Article
  2. Osmotic control of proU transcription is mediated through direct action of potassium glutamate on the transcription complex. Prince WS, et al. J Biol Chem, 1990 Oct 15. PMID 1976630
  3. Osmoregulation in Escherichia coli: complementation analysis and gene-protein relationships in the proU locus. Dattananda CS, et al. J Bacteriol, 1989 Apr. PMID 2649478, Free PMC Article
  4. Cloned structural genes for the osmotically regulated binding-protein-dependent glycine betaine transport system (ProU) of Escherichia coli K-12. Faatz E, et al. Mol Microbiol, 1988 Mar. PMID 2837616
  5. Purification and characterization of a glycine betaine binding protein from Escherichia coli. Barron A, et al. J Biol Chem, 1987 Aug 25. PMID 3305496

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables amine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carnitine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in amine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in carnitine transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to osmotic stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in choline transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycine betaine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glycine betaine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycine betaine transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within glycine betaine transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in glycine import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within hyperosmotic response IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within hyperosmotic response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ATP-binding cassette (ABC) transporter complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ATP-binding cassette (ABC) transporter complex ISM
Inferred from Sequence Model
more info
 PubMed 
part_of ProVWX complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glycine betaine ABC transporter membrane subunit ProW
NP_417164.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2806010..2807074
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417164.1 glycine betaine ABC transporter membrane subunit ProW [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417164.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A797HWJ6
    Conserved Domains (1) summary
    PRK10952
    Location:1 → 354
    PRK10952; proline/glycine betaine ABC transporter permease ProW
Nucleotide Protein
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