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pyrF orotidine-5'-phosphate decarboxylase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947121, updated on 30-Jul-2025
Official Symbol
pyrF
Official Full Name
orotidine-5'-phosphate decarboxylase
Primary source
ECOCYC:EG10809
Locus tag
b1281
See related
ASAP:ABE-0004304
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1276
Summary
Orotidine-5'-phosphate-decarboxylase (PyrF) catalyzes the synthesis of |FRAME: [More information is available at EcoCyc: EG10809].
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Sequence:
NC_000913.3 (1341921..1342658)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene lipopolysaccharide assembly protein A Neighboring gene lipopolysaccharide assembly protein B Neighboring gene putative translation factor Neighboring gene osmotically-inducible lipoprotein OsmB Neighboring gene DNA-binding transcriptional dual regulator YciT

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Substrate binding induces domain movements in orotidine 5'-monophosphate decarboxylase. Harris P, et al. J Mol Biol, 2002 May 10. PMID 12054799
  2. Orotic acid excretion in some wild-type strains of Escherichia coli K-12. Womack JE, et al. J Bacteriol, 1978 Nov. PMID 361725, Free PMC Article
  3. Cloning and physical analysis of the pyrF gene (coding for orotidine-5'-phosphate decarboxylase) from Escherichia coli K-12. Donovan WP, et al. Gene, 1983 Nov. PMID 6319231
  4. Purification and characterization of orotidine-5'-phosphate decarboxylase from Escherichia coli K-12. Donovan WP, et al. J Bacteriol, 1983 Nov. PMID 6355062, Free PMC Article
  5. Structural basis for the catalytic mechanism of a proficient enzyme: orotidine 5'-monophosphate decarboxylase. Harris P, et al. Biochemistry, 2000 Apr 18. PMID 10757968

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables carboxy-lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables orotidine-5'-phosphate decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables orotidine-5'-phosphate decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables orotidine-5'-phosphate decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' UMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within 'de novo' pyrimidine nucleobase biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nucleobase-containing small molecule interconversion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pyrimidine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
orotidine-5'-phosphate decarboxylase
NP_415797.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1341921..1342658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415797.1 orotidine-5'-phosphate decarboxylase

    See identical proteins and their annotated locations for NP_415797.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S7TNW0
    Conserved Domains (1) summary
    PRK00230
    Location:13 → 243
    PRK00230; orotidine-5'-phosphate decarboxylase
Nucleotide Protein
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