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patA putrescine aminotransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947120, updated on 23-Apr-2026
Official Symbol
patA
Official Full Name
putrescine aminotransferase
Primary source
ECOCYC:G7596
Locus tag
b3073
See related
ASAP:ABE-0010092
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3063; oat; pat; ygjG
Summary
PatA(YgjG) and Prr(YdcW) form an alternative to the Puu pathway converting putrescine to gamma-aminobutyric acid (Samsonova, 2005). [More information is available at EcoGene: EG12718]. Putrescine transaminase catalyzes the first step in the putrescine degradative pathway, whereby putrescine is converted into 4-aminobutyrate via 4-aminobutyraldehyde . [More information is available at EcoCyc: G7596].
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Sequence:
NC_000913.3 (3219494..3220873)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor NfeR Neighboring gene aerotaxis receptor Neighboring gene putative tRNA-binding protein YgjH Neighboring gene DNA-binding transcriptional repressor EbgR

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structure of putrescine aminotransferase from Escherichia coli provides insights into the substrate specificity among class III aminotransferases. Cha HJ, et al. PLoS One, 2014. PMID 25423189, Free PMC Article
  2. Two mechanisms for putrescine-dependent transcriptional expression of the putrescine aminotransferase gene, ygjG, in Escherichia coli. Kim YS, et al. Arch Microbiol, 2014 Sep. PMID 24906570
  3. Crystallization and preliminary X-ray crystallographic analysis of YgjG from Escherichia coli. Yeo SJ, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012 Sep 1. PMID 22949197, Free PMC Article
  4. PURIFICATION AND PROPERTIES OF A DIAMINE ALPHA-KETOGLUTARATE TRANSAMINASE FROM ESCHERICHIA COLI. KIM KH. J Biol Chem, 1964 Mar. PMID 14154456
  5. Control of utilization of L-arginine, L-ornithine, agmatine, and putrescine as nitrogen sources in Escherichia coli K-12. Shaibe E, et al. J Bacteriol, 1985 Sep. PMID 3897202, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. rpoS is required for putrescine-dependent ygjG-lacZ expression, but the effect of putrescine on this expression is not caused by simple modulation of RpoS synthesis
    Title: Two mechanisms for putrescine-dependent transcriptional expression of the putrescine aminotransferase gene, ygjG, in Escherichia coli.
  2. crystal belonged to the primitive orthorhombic space group P2(1)2(1)2(1), with unit-cell parameters a = 121.1, b = 129.5, c = 131.3 A, and is estimated to contain four molecules of YgjG per asymmetric unit
    Title: Crystallization and preliminary X-ray crystallographic analysis of YgjG from Escherichia coli.
  3. Expression of E. coli K12 ygjG coding region revealed sigma54-depended ORF which encodes a 459-amino acid protein with putrescine:2-OG aminotransferase activity.
    Title: Molecular cloning and characterization of Escherichia coli K12 ygjG gene.
Submit: New GeneRIF Correction

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables diamine:2-oxoglutarate transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables putrescine:2-oxoglutarate transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables putrescine:2-oxoglutarate transaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables putrescine:2-oxoglutarate transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables putrescine:2-oxoglutarate transaminase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-lysine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in arginine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in putrescine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within putrescine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in putrescine catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within putrescine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
putrescine aminotransferase
NP_417544.5

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3219494..3220873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417544.5 putrescine aminotransferase

    See identical proteins and their annotated locations for NP_417544.5

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0E0XVP7
    Conserved Domains (1) summary
    PRK11522
    Location:1 → 459
    PRK11522; putrescine--2-oxoglutarate aminotransferase; Provisional
Nucleotide Protein
Heading Accession and Version

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