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cnoX chaperedoxin [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947119, updated on 17-Jul-2025
Official Symbol
cnoX
Official Full Name
chaperedoxin
Primary source
ECOCYC:G6268
Locus tag
b0492
See related
ASAP:ABE-0001707
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0486; ybbN
Summary
The function of YbbN as both an thiol-disulfide oxidoreductase and as a chaperone is controversial (Vlamis-Gardikas, 2008): [More information is available at EcoGene: EG13261]. YbbN is a thioredoxin-like protein with chaperone and protein oxidoreductase activity. [More information is available at EcoCyc: G6268].
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Sequence:
NC_000913.3 (517425..518279, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene NfeD-like family protein YbbJ Neighboring gene PHB domain-containing protein QmcA Neighboring gene putative iron ABC exporter ATP-binding subunit FetA Neighboring gene putative iron ABC exporter membrane subunit FetB Neighboring gene NADP(+)-dependent aldehyde reductase YbbO Neighboring gene multifunctional acyl-CoA thioesterase I and protease I and lysophospholipase L1 Neighboring gene putative ABC transporter ATP-binding protein YbbA Neighboring gene putative ABC transporter membrane subunit YbbP

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. DNA replication defects in a mutant deficient in the thioredoxin homolog YbbN. Le HT, et al. Biochem Biophys Res Commun, 2011 Feb 4. PMID 21195694
  2. The multiple functions of the thiol-based electron flow pathways of Escherichia coli: Eternal concepts revisited. Vlamis-Gardikas A. Biochim Biophys Acta, 2008 Nov. PMID 18423382
  3. The origami of thioredoxin-like folds. Pan JL, et al. Protein Sci, 2006 Oct. PMID 17008712, Free PMC Article
  4. CnoX Is a Chaperedoxin: A Holdase that Protects Its Substrates from Irreversible Oxidation. Goemans CV, et al. Mol Cell, 2018 May 17. PMID 29754824
  5. The thioredoxin homolog YbbN functions as a chaperone rather than as an oxidoreductase. Kthiri F, et al. Biochem Biophys Res Commun, 2008 Oct 3. PMID 18657513

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that the DNA replication and cell division defects of the ybbN mutant might best be explained by chaperone functions of YbbN in the biogenesis of DNA polymerase 3 holoenzyme.
    Title: DNA replication defects in a mutant deficient in the thioredoxin homolog YbbN.
  2. The chaperone properties of YbbN are more important in vivo than its redox properties.
    Title: The thioredoxin homolog YbbN functions as a chaperone rather than as an oxidoreductase.
  3. YbbN catalyzes the oxidation of reduced RNase and the isomerization of scrambled RNase. YbbN also possesses chaperone properties.
    Title: The Escherichia coli thioredoxin homolog YbbN/Trxsc is a chaperone and a weak protein oxidoreductase.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables unfolded protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within maintenance of unfolded protein IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein refolding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
chaperedoxin

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    517425..518279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415025.4 chaperedoxin

    See identical proteins and their annotated locations for NP_415025.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0AAN3IKI2
    Conserved Domains (2) summary
    COG3118
    Location:1 → 284
    YbbN; Negative regulator of GroEL, contains thioredoxin-like and TPR-like domains [Posttranslational modification, protein turnover, chaperones]
    sd00008
    Location:114 → 143
    TPR_YbbN; TPR repeat [structural motif]
Nucleotide Protein
Heading Accession and Version

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