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rcnR DNA-binding transcriptional repressor RcnR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947114, updated on 30-Jul-2025
Official Symbol
rcnR
Official Full Name
DNA-binding transcriptional repressor RcnR
Primary source
ECOCYC:G7137
Locus tag
b2105
See related
ASAP:ABE-0006964
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2098; yohL
Summary
The RcnR-rcnA promoter interaction is inhibited by nickel and cobalt; an rcnR mutant constitutively expresses rcnA (Iwig, 2006). rcnR and frmR are paralogs. [More information is available at EcoGene: EG14070]. The RcnR (resistance to cobalt and nickel regulator) protein is an addition to the set of transcriptional metallo-regulator proteins of Escherichia coli (some of the main ones are Fur, CueR, CusR, MntR, Zur, ZntR, and NikR) , regulating the transcriptional expression of a recently described efflux protein, RcnA , to maintain nickel and cobalt homeostasis . [More information is available at EcoCyc: G7137].
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Sequence:
NC_000913.3 (2185524..2185796, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative glycosyl hydrolase YegX Neighboring gene bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase Neighboring gene hydroxyethylthiazole kinase Neighboring gene Ni(2(+))/Co(2(+)) exporter Neighboring gene periplasmic protein involved in Ni/Co export

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Mycobacterium tuberculosis NmtR harbors a nickel sensing site with parallels to Escherichia coli RcnR. Reyes-Caballero H, et al. Biochemistry, 2011 Sep 20. PMID 21819125, Free PMC Article
  2. DNA recognition and wrapping by Escherichia coli RcnR. Iwig JS, et al. J Mol Biol, 2009 Oct 23. PMID 19703465
  3. Ni(II) and Co(II) sensing by Escherichia coli RcnR. Iwig JS, et al. J Am Chem Soc, 2008 Jun 18. PMID 18505253, Free PMC Article
  4. The RcnRA (YohLM) system of Escherichia coli: a connection between nickel, cobalt and iron homeostasis. Koch D, et al. Biometals, 2007 Oct. PMID 17120142
  5. Nickel homeostasis in Escherichia coli - the rcnR-rcnA efflux pathway and its linkage to NikR function. Iwig JS, et al. Mol Microbiol, 2006 Oct. PMID 16956381

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of protein-DNA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
DNA-binding transcriptional repressor RcnR

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2185524..2185796 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416608.1 DNA-binding transcriptional repressor RcnR

    See identical proteins and their annotated locations for NP_416608.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2X1NCR4
    Conserved Domains (1) summary
    PRK15039
    Location:1 → 90
    PRK15039; Ni(II)/Co(II)-binding transcriptional repressor RcnR
Nucleotide Protein
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