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recN DNA repair protein RecN [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947105, updated on 17-Jul-2025
Official Symbol
recN
Official Full Name
DNA repair protein RecN
Primary source
ECOCYC:EG10831
Locus tag
b2616
See related
ASAP:ABE-0008611
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2612; radB
Summary
LexA regulon. [More information is available at EcoGene: EG10831]. RecN is required for repair of double strand breaks in the chromosome when these breaks occur at two or more locations, but not when there is a single break in the chromosome. [More information is available at EcoCyc: EG10831].
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Sequence:
NC_000913.3 (2751795..2753456)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene nucleotide exchange factor GrpE Neighboring gene NAD kinase Neighboring gene outer membrane protein assembly factor BamE Neighboring gene putative component of the Rsx system Neighboring gene ribosome association toxin RatA

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Protease-deficient SOS constitutive cells have RecN-dependent cell division phenotypes. Warr AR, et al. Mol Microbiol, 2019 Feb. PMID 30422330, Free PMC Article
  2. Lipid deficiency in a lipoprotein mutant of Escherichia coli. Rotering H, et al. FEBS Lett, 1977 Nov 1. PMID 336401
  3. The recN locus of Escherichia coli K12: molecular analysis and identification of the gene product. Picksley SM, et al. Mol Gen Genet, 1985. PMID 3003532
  4. Genetic and phenotypic analyses indicating occurrence of the recN262 and radB101 mutations at the same locus in Escherichia coli. Sargentini NJ, et al. J Bacteriol, 1988 May. PMID 3283110, Free PMC Article
  5. Inducible expression of a gene specific to the RecF pathway for recombination in Escherichia coli K12. Lloyd RG, et al. Mol Gen Genet, 1983. PMID 6343801

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An Epistasis Analysis of recA and recN in Escherichia coli K-12.
    Title: An Epistasis Analysis of recA and recN in Escherichia coli K-12.
  2. UV-irradiated Escherichia coli cells with a recN mutation did not exhibit increased nucleoid condensation, but chromosome replication and cytokinesis occurred. In the uvrA and recJ strains, the condensation step was delayed compared to the wild-type strain, and chromosome replication and cytokinesis did not occur.
    Title: Influence of uvrA, recJ and recN gene mutations on nucleoid reorganization in UV-treated Escherichia coli cells.
  3. The only SOS gene required (of 19 tested) for the cell length phenotype is recN.
    Title: Protease-deficient SOS constitutive cells have RecN-dependent cell division phenotypes.
  4. The DNA damage-induced DNA compaction was found to be dependent on the recombination proteins RecA, RecO and RecR as well as the SOS-inducible, SMC (structural maintenance of chromosomes)-like protein RecN.
    Title: DNA compaction in the early part of the SOS response is dependent on RecN and RecA.
  5. Data suggest that RecN plays a crucial role in homologous recombination-dependent DSB repair and that it is required upstream of RecA-mediated strand exchange.
    Title: RecA protein recruits structural maintenance of chromosomes (SMC)-like RecN protein to DNA double-strand breaks.
  6. a role for RecN in protecting the chromosome from break-induced chromosome rearrangements
    Title: RecN protein and transcription factor DksA combine to promote faithful recombinational repair of DNA double-strand breaks.
  7. ClpXP is a critical factor in the cellular clearance of cytoplasmic RecN aggregates from the cell and therefore plays an important role in DNA damage tolerance
    Title: Degradation of Escherichia coli RecN aggregates by ClpXP protease and its implications for DNA damage tolerance.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding ISM
Inferred from Sequence Model
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in SOS response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within SOS response IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within double-strand break repair IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within double-strand break repair via homologous recombination EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within recombinational interstrand cross-link repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within recombinational repair IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to UV IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to X-ray IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to radiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in bacterial nucleoid IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in bacterial nucleoid IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
DNA repair protein RecN

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2751795..2753456
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_026172.1 DNA repair protein RecN

    See identical proteins and their annotated locations for YP_026172.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5B9APR3
    Conserved Domains (1) summary
    PRK10869
    Location:1 → 553
    PRK10869; recombination and repair protein; Provisional
Nucleotide Protein
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