recN [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: recN
Primary source: ECOCYC:EG10831
Locus tag: b2616
See related: ASAP:ABE-0008611
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK2612; radB
Summary: LexA regulon. [More information is available at EcoGene: EG10831]. RecN is required for repair of double strand breaks in the chromosome when these breaks occur at two or more locations, but not when there is a single break in the chromosome. [More information is available at EcoCyc: EG10831].
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Genomic context

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Sequence:: NC_000913.3 (2751795..2753456)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An Epistasis Analysis of recA and recN in Escherichia coli K-12.
Title: An Epistasis Analysis of recA and recN in Escherichia coli K-12.
UV-irradiated Escherichia coli cells with a recN mutation did not exhibit increased nucleoid condensation, but chromosome replication and cytokinesis occurred. In the uvrA and recJ strains, the condensation step was delayed compared to the wild-type strain, and chromosome replication and cytokinesis did not occur.
Title: Influence of uvrA, recJ and recN gene mutations on nucleoid reorganization in UV-treated Escherichia coli cells.
The only SOS gene required (of 19 tested) for the cell length phenotype is recN.
Title: Protease-deficient SOS constitutive cells have RecN-dependent cell division phenotypes.
The DNA damage-induced DNA compaction was found to be dependent on the recombination proteins RecA, RecO and RecR as well as the SOS-inducible, SMC (structural maintenance of chromosomes)-like protein RecN.
Title: DNA compaction in the early part of the SOS response is dependent on RecN and RecA.
Data suggest that RecN plays a crucial role in homologous recombination-dependent DSB repair and that it is required upstream of RecA-mediated strand exchange.
Title: RecA protein recruits structural maintenance of chromosomes (SMC)-like RecN protein to DNA double-strand breaks.
a role for RecN in protecting the chromosome from break-induced chromosome rearrangements
Title: RecN protein and transcription factor DksA combine to promote faithful recombinational repair of DNA double-strand breaks.
ClpXP is a critical factor in the cellular clearance of cytoplasmic RecN aggregates from the cell and therefore plays an important role in DNA damage tolerance
Title: Degradation of Escherichia coli RecN aggregates by ClpXP protease and its implications for DNA damage tolerance.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISM Inferred from Sequence Model more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in SOS response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within SOS response	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within double-strand break repair	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within double-strand break repair via homologous recombination	EXP Inferred from Experiment more info	PubMed
acts_upstream_of_or_within recombinational interstrand cross-link repair	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within recombinational repair	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to UV	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to X-ray	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to ionizing radiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to radiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to radiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in bacterial nucleoid	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: DNA repair protein RecN

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

2751795..2753456

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

YP_026172.1 DNA repair protein RecN [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for YP_026172.1

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A5B9APR3

Conserved Domains (1) summary

PRK10869
Location:1 → 553

PRK10869; recombination and repair protein; Provisional