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malI DNA-binding transcriptional repressor MalI [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947104, updated on 30-Jul-2025
Official Symbol
malI
Official Full Name
DNA-binding transcriptional repressor MalI
Primary source
ECOCYC:EG10557
Locus tag
b1620
See related
ASAP:ABE-0005421
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1615
Summary
"Maltose inhibitor," MalI, is a repressor that controls genes related to the maltose system. [More information is available at EcoCyc: EG10557].
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Sequence:
NC_000913.3 (1698152..1699180, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor UidR Neighboring gene 7-alpha-hydroxysteroid dehydrogenase Neighboring gene PTS enzyme IIBC component MalX Neighboring gene negative regulator of MalT activity/cystathionine beta-lyase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Targets for the MalI repressor at the divergent Escherichia coli K-12 malX-malI promoters. Lloyd GS, et al. FEMS Microbiol Lett, 2010 Apr. PMID 20141531
  2. Adaptive prediction of environmental changes by microorganisms. Mitchell A, et al. Nature, 2009 Jul 9. PMID 19536156
  3. Transcription initiation in the Escherichia coli K-12 malI-malX intergenic region and the role of the cyclic AMP receptor protein. Lloyd GS, et al. FEMS Microbiol Lett, 2008 Nov. PMID 19054084
  4. Identification of endogenous inducers of the mal regulon in Escherichia coli. Ehrmann M, et al. J Bacteriol, 1987 Aug. PMID 3038842, Free PMC Article
  5. MalI, a novel protein involved in regulation of the maltose system of Escherichia coli, is highly homologous to the repressor proteins GalR, CytR, and LacI. Reidl J, et al. J Bacteriol, 1989 Sep. PMID 2670898, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The malI promoter is repressed by MalI binding from position +3 to position +18, downstream of the malI transcript start.
    Title: Targets for the MalI repressor at the divergent Escherichia coli K-12 malX-malI promoters.
  2. The malI promoter drives transcription initiation from a location 85 bp upstream from the malX transcript start and it is active without the CRP. Expression from the malI promoter can be stimulated by the CRP.
    Title: Transcription initiation in the Escherichia coli K-12 malI-malX intergenic region and the role of the cyclic AMP receptor protein.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of protein-DNA complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Preferred Names
DNA-binding transcriptional repressor MalI

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1698152..1699180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416137.1 DNA-binding transcriptional repressor MalI

    See identical proteins and their annotated locations for NP_416137.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S7CKF0
    Conserved Domains (1) summary
    PRK10014
    Location:1 → 342
    PRK10014; DNA-binding transcriptional repressor MalI; Provisional
Nucleotide Protein
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