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norW NADH:flavorubredoxin reductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947088, updated on 19-Sep-2024

Summary

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Official Symbol
norW
Official Full Name
NADH:flavorubredoxin reductase
Primary source
ECOCYC:EG12450
Locus tag
b2711
See related
ASAP:ABE-0008912
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2706; ygaL; ygbD
Summary
Upregulated by GSNO in defined medium (anaerobic). [More information is available at EcoGene: EG12450]. NorW encodes the reductase enzyme which can convert oxidized flavorubredoxin to its reduced form . [More information is available at EcoCyc: EG12450].
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Genomic context

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Sequence:
NC_000913.3 (2833912..2835045)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor SrlR Neighboring gene D-arabinose 5-phosphate isomerase GutQ Neighboring gene DNA-binding transcriptional dual regulator NorR Neighboring gene anaerobic nitric oxide reductase flavorubredoxin Neighboring gene carbamoyl--[HypE] ligase Neighboring gene putative electron transport protein HydN

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel type of nitric-oxide reductase. Escherichia coli flavorubredoxin. Gomes CM, et al. J Biol Chem, 2002 Jul 12. PMID 12101220
  2. Spectroscopic studies and characterization of a novel electron-transfer chain from Escherichia coli involving a flavorubredoxin and its flavoprotein reductase partner. Gomes CM, et al. Biochemistry, 2000 Dec 26. PMID 11123953
  3. DNA binding activity of the Escherichia coli nitric oxide sensor NorR suggests a conserved target sequence in diverse proteobacteria. Tucker NP, et al. J Bacteriol, 2004 Oct. PMID 15375149, Free PMC Article
  4. Regulation of the flavorubredoxin nitric oxide reductase gene in Escherichia coli: nitrate repression, nitrite induction, and possible post-transcription control. da Costa PN, et al. FEMS Microbiol Lett, 2003 Jan 28. PMID 12586421
  5. The NorR protein of Escherichia coli activates expression of the flavorubredoxin gene norV in response to reactive nitrogen species. Hutchings MI, et al. J Bacteriol, 2002 Aug. PMID 12142437, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables rubredoxin-NAD+ reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to nitric oxide IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within nitric oxide catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NADH:flavorubredoxin reductase
NP_417191.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2833912..2835045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417191.1 NADH:flavorubredoxin reductase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417191.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N8QZG9
    Conserved Domains (1) summary
    PRK04965
    Location:1 → 376
    PRK04965; NADH:flavorubredoxin reductase NorW
Nucleotide Protein
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