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aroF 3-deoxy-7-phosphoheptulonate synthase, Tyr-sensitive [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947084, updated on 6-Jul-2026
Official Symbol
aroF
Official Full Name
3-deoxy-7-phosphoheptulonate synthase, Tyr-sensitive
Primary source
ECOCYC:EG10078
Locus tag
b2601
See related
ASAP:ABE-0008549
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2598
Summary
aroF and tyrA encoding the bifunctional chorismate mutase prephenate dehydrogenase form the tyrosine operon. [More information is available at EcoCyc: EG10078].
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Sequence:
NC_000913.3 (2740080..2741150, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene fused chorismate mutase/prephenate dehydratase Neighboring gene fused chorismate mutase/prephenate dehydrogenase Neighboring gene DUF2799 domain-containing lipoprotein YfiL Neighboring gene DUF4154 domain-containing protein YfiR Neighboring gene diguanylate cyclase DgcN

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Overexpression, purification, and characterization of tyrosine-sensitive 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthase from Escherichia coli. Ramilo CA, et al. Protein Expr Purif, 1997 Mar. PMID 9056491
  2. 3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase. Purification, properties, and kinetics of the tyrosine-sensitive isoenzyme from Escherichia coli. Schoner R, et al. J Biol Chem, 1976 Sep 25. PMID 9387
  3. DNA looping. Schleif R. Annu Rev Biochem, 1992. PMID 1497310
  4. Regulation of the Salmonella typhimurium aroF gene in Escherichia coli. Muday GK, et al. J Bacteriol, 1990 May. PMID 1970560, Free PMC Article
  5. Cloning of an aroF allele encoding a tyrosine-insensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase. Weaver LM, et al. J Bacteriol, 1990 Nov. PMID 1977738, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3-deoxy-7-phosphoheptulonate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-deoxy-7-phosphoheptulonate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-deoxy-7-phosphoheptulonate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aromatic amino acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in aromatic amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within aromatic amino acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chorismate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
3-deoxy-7-phosphoheptulonate synthase, Tyr-sensitive
NP_417092.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2740080..2741150 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417092.1 3-deoxy-7-phosphoheptulonate synthase, Tyr-sensitive

    See identical proteins and their annotated locations for NP_417092.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0H2V9U5
    Conserved Domains (1) summary
    PRK12755
    Location:1 → 353
    PRK12755; phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional
Nucleotide Protein
Heading Accession and Version

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