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ung uracil-DNA glycosylase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947067, updated on 23-Nov-2021

Summary

Gene symbol
ung
Gene description
uracil-DNA glycosylase
Primary source
ASAP:ABE-0008495
Locus tag
b2580
See related
ECOCYC:EG11058
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2578
Summary
UDG and Ndk form a complex (Goswami, 2006). [More information is available at EcoGene: EG11058]. Uracil can be generated in DNA as a result of misincorporation by DNA polymerase, spontaneous deamination of cytosine, and deamination of cytosine induced by bisulfite or nitrous acid. [More information is available at EcoCyc: EG11058].
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Genomic context

Sequence:
NC_000913.3 (2716754..2717443)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene cysteine/O-acetylserine exporter EamB Neighboring gene stress-induced alternate pyruvate formate-lyase subunit Neighboring gene putative methyltransferase YfiF Neighboring gene reduced thioredoxin 2

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, hydrolyzing N-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables uracil DNA N-glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables uracil DNA N-glycosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables uracil DNA N-glycosylase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in base-excision repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within base-excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in base-excision repair, AP site formation via deaminated base removal IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
uracil-DNA glycosylase
NP_417075.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2716754..2717443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417075.1 Peptide Sequence

    See identical proteins and their annotated locations for NP_417075.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P12295
    Conserved Domains (2) summary
    PRK05254
    Location:4220
    PRK05254; uracil-DNA glycosylase; Provisional
    cd10027
    Location:6266
    UDG-F1-like; motif A [structural motif]
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