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rseA anti-sigma-E factor RseA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947053, updated on 26-Mar-2025
Official Symbol
rseA
Official Full Name
anti-sigma-E factor RseA
Primary source
ECOCYC:EG12341
Locus tag
b2572
See related
ASAP:ABE-0008462
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2570; mclA; yfiJ
Summary
The anti-sigma N-terminal RseA domain is linked to the periplasmic domain by a single membrane domain spanning residues 100-118. [More information is available at EcoGene: EG12341]. RseA is an anti-sigma factor that inhibits sigma E . [More information is available at EcoCyc: EG12341].
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Sequence:
NC_000913.3 (2708754..2709404, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 30S ribosomal subunit biogenesis factor LepA Neighboring gene protein RseC Neighboring gene anti-sigma factor stabilizing protein RseB Neighboring gene RNA polymerase sigma factor RpoE Neighboring gene rpoE leader peptide Neighboring gene L-aspartate oxidase Neighboring gene tRNA m(6)A37 methyltransferase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A conserved activation cluster is required for allosteric communication in HtrA-family proteases. de Regt AK, et al. Structure, 2015 Mar 3. PMID 25703375, Free PMC Article
  2. Functional equivalence of Escherichia coli sigma E and Pseudomonas aeruginosa AlgU: E. coli rpoE restores mucoidy and reduces sensitivity to reactive oxygen intermediates in algU mutants of P. aeruginosa. Yu H, et al. J Bacteriol, 1995 Jun. PMID 7768826, Free PMC Article
  3. Interaction of the conserved region 4.2 of sigma(E) with the RseA anti-sigma factor. Tam C, et al. J Biol Chem, 2002 Jul 26. PMID 12016219
  4. Regulation of the alternative sigma factor sigma(E) during initiation, adaptation, and shutoff of the extracytoplasmic heat shock response in Escherichia coli. Ades SE, et al. J Bacteriol, 2003 Apr. PMID 12670975, Free PMC Article
  5. Crystal structure of Escherichia coli sigmaE with the cytoplasmic domain of its anti-sigma RseA. Campbell EA, et al. Mol Cell, 2003 Apr. PMID 12718891

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study concludes that recognition of the cleaved amino acid by the RseP PDZ domain is not essential for sequential cleavage of RseA and sigma(E) stress response in vivo
    Title: PDZ domains of RseP are not essential for sequential cleavage of RseA or stress-induced σ(E) activation in vivo.
  2. Results show RseB binds to RseA and inhibits its sequential cleavage, thereby functioning as a negative modulator of this response.
    Title: Structural basis for the negative regulation of bacterial stress response by RseB.
  3. after DegS cleavage, the newly exposed carboxyl terminus of RseA may facilitate Site-2 cleavage through direct interaction with the PDZ domain.
    Title: Cleavage of RseA by RseP requires a carboxyl-terminal hydrophobic amino acid following DegS cleavage.
  4. RseP catalyzes proteolytic cleavage of the membrane-bound anti-sigma(E) protein RseA as an essential step in transmembrane signal transduction in the sigma(E) extracytoplasmic stress response pathway.
    Title: Substrate recognition and binding by RseP, an Escherichia coli intramembrane protease.
  5. Although DegS cleavage of RseA is normally activated by binding of the C termini of porins to the PDZ domain of DegS, RseB inhibition is independent of this activation mechanism
    Title: Inhibition of regulated proteolysis by RseB.
  6. two RseAs bind to the grooves of the dimeric RseB by conserved residues
    Title: Crystal structure of RseB and a model of its binding mode to RseA.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables molecular adaptor activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sigma factor antagonist activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sigma factor antagonist activity IEA
Inferred from Electronic Annotation
more info
  
enables sigma factor antagonist activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within response to stress IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
part_of sigma factor antagonist complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
anti-sigma-E factor RseA

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2708754..2709404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417067.1 anti-sigma-E factor RseA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417067.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A192CB16, A0A1X3J2N8, A0A1X3JFD7, F4T2A9
    Conserved Domains (1) summary
    PRK10863
    Location:1 → 216
    PRK10863; anti-sigma-E factor RseA
Nucleotide Protein
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