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bolA DNA-binding transcriptional dual regulator BolA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947043, updated on 3-Dec-2024
Official Symbol
bolA
Official Full Name
DNA-binding transcriptional dual regulator BolA
Primary source
ECOCYC:EG10125
Locus tag
b0435
See related
ASAP:ABE-0001508
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0429
Summary
Although BolA is considered a transcriptional regulator, further characterization is needed to complete this assessment. [More information is available at EcoCyc: EG10125].
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Sequence:
NC_000913.3 (454472..454789)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene muropeptide:H(+) symporter Neighboring gene putative lipoprotein YajG Neighboring gene trigger factor Neighboring gene ATP-dependent Clp protease proteolytic subunit

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. BolA Is Required for the Accurate Regulation of c-di-GMP, a Central Player in Biofilm Formation. Moreira RN, et al. mBio, 2017 Sep 19. PMID 28928205, Free PMC Article
  2. Phosphorylation status of BolA affects its role in transcription and biofilm development. Galego L, et al. FEBS J, 2021 Feb. PMID 32535996
  3. BolA is a transcriptional switch that turns off motility and turns on biofilm development. Dressaire C, et al. mBio, 2015 Feb 17. PMID 25691594, Free PMC Article
  4. Breaking through the stress barrier: the role of BolA in Gram-negative survival. Guinote IB, et al. World J Microbiol Biotechnol, 2014 Oct. PMID 25038865
  5. Stationary-phase-inducible "gearbox" promoters: differential effects of katF mutations and role of sigma 70. Bohannon DE, et al. J Bacteriol, 1991 Jul. PMID 1906064, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphorylation status of BolA affects its role in transcription and biofilm development.
    Title: Phosphorylation status of BolA affects its role in transcription and biofilm development.
  2. study unravelled a direct connection between the bolA morphogene and the signaling molecule c-di-GMP; show the important cross-talk that occurs between these two molecular regulators during the transition between the motile/planktonic and adhesive/sessile lifestyles in E. coli
    Title: BolA Is Required for the Accurate Regulation of c-di-GMP, a Central Player in Biofilm Formation.
  3. In the presence of bolA, E. coli cells were able to attach to the stainless steel and silicone.
    Title: Role of bolA and rpoS genes in biofilm formation and adherence pattern by Escherichia coli K-12 MG1655 on polypropylene, stainless steel, and silicone surfaces.
  4. These data show that BolA is a new bacterial transcription factor that modulates the switch from a planktonic to a sessile lifestyle.
    Title: BolA is a transcriptional switch that turns off motility and turns on biofilm development.
  5. Authors summarize current knowledge on the role of BolA, mainly in E. coli, and discuss its implication in global regulation in relation to stress. [Review]
    Title: Breaking through the stress barrier: the role of BolA in Gram-negative survival.
  6. E. coli K-12 MG1655, rpoS, and bolA mutant strains were used and gene expression was studied. Results show that both genes contribute to the ability to respond and adapt in response to various types of stresses
    Title: Analysis of rpoS and bolA gene expression under various stress-induced environments in planktonic and biofilm phase using 2(-ΔΔCT) method.
  7. a new insight into the bolA regulation network demonstrating that H-NS represses the transcription of this important gene was provided.
    Title: A new target for an old regulator: H-NS represses transcription of bolA morphogene by direct binding to both promoters.
  8. The present report shows that BolA is a transcriptional regulator of the dacA and dacC genes, thus regulating both DD-carboxypeptidases PBP5 and PBP6 and thereby demonstrating the versatility of BolA as a cellular regulator.
    Title: BolA affects cell growth, and binds to the promoters of penicillin-binding proteins 5 and 6 and regulates their expression.
  9. alterations in cell morphology induced by bolA seem to be mediated by a complex pathway that integrates PBP5, PBP6, MreB, and probably other regulators of cell morphology/elongation.
    Title: BolA inhibits cell elongation and regulates MreB expression levels.
  10. In this report it is shown that endoribonuclease RNase III acts as a post-transcriptional modulator of bolA expression under carbon starvation conditions
    Title: Adaptation to carbon starvation: RNase III ensures normal expression levels of bolA1p mRNA and sigma(S).
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA-templated transcription IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in cell redox homeostasis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in intracellular iron ion homeostasis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in iron-sulfur cluster assembly NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of iron-sulfur cluster assembly complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
DNA-binding transcriptional dual regulator BolA

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    454472..454789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414969.4 DNA-binding transcriptional dual regulator BolA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414969.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A4D1PYY8
    Conserved Domains (1) summary
    PRK11628
    Location:1 → 105
    PRK11628; transcriptional regulator BolA; Provisional
Nucleotide Protein
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