recO [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: recO
Primary source: ECOCYC:EG10832
Locus tag: b2565
See related: ASAP:ABE-0008438
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK2563
Summary: In Escherichia coli replication is temporarily inhibited after DNA damage, such as caused by UV, but resumes following a period of time commensurate with the removal of the lesions . [More information is available at EcoCyc: EG10832].
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Genomic context

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Sequence:: NC_000913.3 (2701741..2702469, complement)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Allosteric effects of SSB C-terminal tail on assembly of E. coli RecOR proteins.
Title: Allosteric effects of SSB C-terminal tail on assembly of E. coli RecOR proteins.
we used genetics and single-molecule fluorescence microscopy to investigate whether RecF and RecO function together, or separately, in live Escherichia coli cells. We identified conditions in which RecF and RecO functions are genetically separable.
Title: RecFOR epistasis group: RecF and RecO have distinct localizations and functions in Escherichia coli.
RecOR, and possibly other SSB-interacting proteins, function(s) in part to alter long-range, macroscopic interactions between or throughout nucleoprotein complexes by microscopically altering wrapping and bridging distant sites.
Title: Imaging and energetics of single SSB-ssDNA molecules reveal intramolecular condensation and insight into RecOR function.
Data show that single-stranded DNA binding proteins (SSB)-interacting proteins RecO, RecG, PriA, and accessory helicase Rep do not correlate with replication at relication forks.
Title: Are the SSB-Interacting Proteins RecO, RecG, PriA and the DnaB-Interacting Protein Rep Bound to Progressing Replication Forks in Escherichia coli?
The DNA damage-induced DNA compaction was found to be dependent on the recombination proteins RecA, RecO and RecR as well as the SOS-inducible, SMC (structural maintenance of chromosomes)-like protein RecN.
Title: DNA compaction in the early part of the SOS response is dependent on RecN and RecA.
Data show that UvrD and UvrD252 counteract RecQ, RecJ, and RecFOR at forks blocked in the rep mutant of Escherichia coli.
Title: UvrD and UvrD252 counteract RecQ, RecJ, and RecFOR in a rep mutant of Escherichia coli.
When an SSB variant that lacks the C-terminal 8 amino acids is used, the capacity of RecOR to facilitate RecA loading onto the ssDNA is largely abolished
Title: SSB protein limits RecOR binding onto single-stranded DNA.
All three recombination mediator proteins RecFOR are needed to build a functionally competent RecA filament that supports efficient Pol V-mediated translesion synthesis in the presence of ssDNA-binding protein.
Title: RecFOR proteins are essential for Pol V-mediated translesion synthesis and mutagenesis.
genetic analysis of recombination in a recB recD double mutant was performed; results show that conjugational recombination and DNA repair in this mutant are highly dependent on recJ, partially dependent on recFOR, and independent of recQ
Title: Effects of recJ, recQ, and recFOR mutations on recombination in nuclease-deficient recB recD double mutants of Escherichia coli.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA recombination	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in recombinational repair	EXP Inferred from Experiment more info	PubMed
involved_in recombinational repair	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to UV	EXP Inferred from Experiment more info	PubMed

Component	Evidence Code	Pubs
is_active_in bacterial nucleoid	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: recombination mediator protein RecO

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

2701741..2702469 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_417060.1 recombination mediator protein RecO [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for NP_417060.1

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A7A3NN10

Conserved Domains (1) summary

PRK00085
Location:1 → 236

recO; DNA repair protein RecO; Reviewed