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purL phosphoribosylformylglycinamide synthetase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947032, updated on 25-Jun-2025
Official Symbol
purL
Official Full Name
phosphoribosylformylglycinamide synthetase
Primary source
ECOCYC:EG10797
Locus tag
b2557
See related
ASAP:ABE-0008412
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2555; purI
Summary
Genetic complementation tests showed that the coli purL gene was divided into three domains. [More information is available at EcoCyc: EG10797].
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Sequence:
NC_000913.3 (2691656..2695543, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene histidine kinase GlrK Neighboring gene ncRNA Neighboring gene membrane-bound lytic murein transglycosylase F Neighboring gene tRNA adenosine(34) deaminase Neighboring gene phosphatidylglycerophosphatase C

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Identification of the enzymatic reactions encoded by the purG and purI genes of Escherichia coli. Houlberg U, et al. J Bacteriol, 1983 Jun. PMID 6343356, Free PMC Article
  2. Formylglycinamide ribonucleotide synthetase from Escherichia coli: cloning, sequencing, overproduction, isolation, and characterization. Schendel FJ, et al. Biochemistry, 1989 Mar 21. PMID 2659070
  3. P-BOSS: a new filtering method for treasure hunting in metabolomics. Morohashi M, et al. J Chromatogr A, 2007 Aug 3. PMID 17400234
  4. Location of purine genes on the physical map of Escherichia coli. Masters M. J Bacteriol, 1990 Mar. PMID 2407714, Free PMC Article
  5. Autoregulation of PurR repressor synthesis and involvement of purR in the regulation of purB, purC, purL, purMN and guaBA expression in Escherichia coli. Meng LM, et al. Eur J Biochem, 1990 Jan 26. PMID 2404765

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Formylglycinamide ribonucleotide synthetase from Escherichia coli: cloning, sequencing, overproduction, isolation, and characterization.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoribosylformylglycinamidine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoribosylformylglycinamidine synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoribosylformylglycinamidine synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within 'de novo' IMP biosynthetic process IC
Inferred by Curator
more info
 PubMed 
acts_upstream_of_or_within glutamine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in purine nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
phosphoribosylformylglycinamide synthetase
YP_026170.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2691656..2695543 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_026170.1 phosphoribosylformylglycinamide synthetase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for YP_026170.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8T5ZYX3, A0AAN4NSI9
    Conserved Domains (1) summary
    PRK05297
    Location:2 → 1295
    PRK05297; phosphoribosylformylglycinamidine synthase; Provisional
Nucleotide Protein
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