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mltF membrane-bound lytic murein transglycosylase F [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947028, updated on 26-Mar-2025

Summary

Official Symbol
mltF
Official Full Name
membrane-bound lytic murein transglycosylase F
Primary source
ECOCYC:EG11373
Locus tag
b2558
See related
ASAP:ABE-0008417
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2556; yfhD
Summary
The N-terminus (22-273) is homologous to ABC-type periplasmic binding proteins; the C-terminus (294-387) encodes the MltF function. [More information is available at EcoGene: EG11373]. MltF is a membrane-bound lytic transglycosylase responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan . [More information is available at EcoCyc: EG11373].
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Genomic context

Sequence:
NC_000913.3 (2695801..2697357)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene phosphoribosylformylglycinamide synthetase Neighboring gene tRNA adenosine(34) deaminase Neighboring gene phosphatidylglycerophosphatase C Neighboring gene putative DNA-binding transcriptional regulator YfhH

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables carbon-oxygen lyase activity, acting on polysaccharides IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidoglycan lytic transglycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptidoglycan lytic transglycosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidoglycan lytic transglycosylase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell wall macromolecule catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidoglycan catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within peptidoglycan catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidoglycan metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell envelope IEA
Inferred from Electronic Annotation
more info
 
is_active_in cell outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
membrane-bound lytic murein transglycosylase F

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2695801..2697357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417053.2 membrane-bound lytic murein transglycosylase F [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417053.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376M6B9
    Conserved Domains (1) summary
    PRK10859
    Location:1483
    PRK10859; membrane-bound lytic murein transglycosylase MltF