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mltF membrane-bound lytic murein transglycosylase F [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947028, updated on 26-Mar-2025

Summary

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Official Symbol
mltF
Official Full Name
membrane-bound lytic murein transglycosylase F
Primary source
ECOCYC:EG11373
Locus tag
b2558
See related
ASAP:ABE-0008417
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2556; yfhD
Summary
The N-terminus (22-273) is homologous to ABC-type periplasmic binding proteins; the C-terminus (294-387) encodes the MltF function. [More information is available at EcoGene: EG11373]. MltF is a membrane-bound lytic transglycosylase responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan . [More information is available at EcoCyc: EG11373].
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Genomic context

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Sequence:
NC_000913.3 (2695801..2697357)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene phosphoribosylformylglycinamide synthetase Neighboring gene tRNA adenosine(34) deaminase Neighboring gene phosphatidylglycerophosphatase C Neighboring gene putative DNA-binding transcriptional regulator YfhH

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Purification, crystallization and preliminary X-ray diffraction analysis of the lytic transglycosylase MltF from Escherichia coli. Madoori PK, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 May 1. PMID 20445253, Free PMC Article
  2. The C-terminal domain of Escherichia coli YfhD functions as a lytic transglycosylase. Scheurwater EM, et al. J Biol Chem, 2008 Mar 28. PMID 18234673, Free PMC Article
  3. Formylglycinamide ribonucleotide synthetase from Escherichia coli: cloning, sequencing, overproduction, isolation, and characterization. Schendel FJ, et al. Biochemistry, 1989 Mar 21. PMID 2659070
  4. Analysis of an Escherichia coli mutant strain resistant to the cell-killing function encoded by the gef gene family. Poulsen LK, et al. Mol Microbiol, 1992 Apr. PMID 1602968
  5. Reactions of all Escherichia coli lytic transglycosylases with bacterial cell wall. Lee M, et al. J Am Chem Soc, 2013 Mar 6. PMID 23421439, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables carbon-oxygen lyase activity, acting on polysaccharides IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidoglycan lytic transglycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidoglycan lytic transglycosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidoglycan lytic transglycosylase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell wall macromolecule catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within peptidoglycan catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidoglycan metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell envelope IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
membrane-bound lytic murein transglycosylase F

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2695801..2697357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417053.2 membrane-bound lytic murein transglycosylase F [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417053.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376M6B9
    Conserved Domains (1) summary
    PRK10859
    Location:1 → 483
    PRK10859; membrane-bound lytic murein transglycosylase MltF
Nucleotide Protein
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