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glnB nitrogen regulatory protein PII-1 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947016, updated on 17-Jul-2025
Official Symbol
glnB
Official Full Name
nitrogen regulatory protein PII-1
Primary source
ECOCYC:EG10384
Locus tag
b2553
See related
ASAP:ABE-0008398
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2550
Summary
GlnB is the archetypal PII protein; a ubiquitous family of small trimeric signal transduction proteins that facilitate regulation of bacterial nitrogen metabolism by controlling the activities of a variety of enzymes, transcription factors and membrane proteins. [More information is available at EcoGene: EG10384]. The protein PII plays a critical role in the regulation of nitrogen metabolism by controlling the level and activity of glutamine synthetase. [More information is available at EcoCyc: EG10384].
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Sequence:
NC_000913.3 (2687070..2687408, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene serine hydroxymethyltransferase Neighboring gene nitric oxide dioxygenase Neighboring gene DNA-binding transcriptional activator GlrR Neighboring gene outer membrane lipoprotein QseG Neighboring gene histidine kinase GlrK

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The bacterial signal transduction protein GlnB regulates the committed step in fatty acid biosynthesis by acting as a dissociable regulatory subunit of acetyl-CoA carboxylase. Gerhardt EC, et al. Mol Microbiol, 2015 Mar. PMID 25557370
  2. Probing interactions of the homotrimeric PII signal transduction protein with its receptors by use of PII heterotrimers formed in vitro from wild-type and mutant subunits. Jiang P, et al. J Bacteriol, 1997 Jul. PMID 9209054, Free PMC Article
  3. X-ray structure of the signal transduction protein from Escherichia coli at 1.9 A. Carr PD, et al. Acta Crystallogr D Biol Crystallogr, 1996 Jan 1. PMID 15299730
  4. Preliminary X-ray diffraction analysis of crystals of the PII protein from Escherichia coli. de Mel VS, et al. J Mol Biol, 1994 Nov 4. PMID 7966297
  5. Activation of the dephosphorylation of nitrogen regulator I-phosphate of Escherichia coli. Liu J, et al. J Bacteriol, 1995 Feb. PMID 7860602, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We provide evidence here that NanE, GlcNAc-6P epimerase, and the uridylylated PII protein allosterically activate NagB by direct protein-protein interactions.
    Title: The Nitrogen Regulatory PII Protein (GlnB) and N-Acetylglucosamine 6-Phosphate Epimerase (NanE) Allosterically Activate Glucosamine 6-Phosphate Deaminase (NagB) in Escherichia coli.
  2. propose that the GlnB protein acts as a 2-oxoglutarate-sensitive dissociable regulatory subunit of acetyl-CoA carboxylase enzyme
    Title: The bacterial signal transduction protein GlnB regulates the committed step in fatty acid biosynthesis by acting as a dissociable regulatory subunit of acetyl-CoA carboxylase.
  3. Data show a subtle interplay between GlnB and GlnK.
    Title: The pivotal regulator GlnB of Escherichia coli is engaged in subtle and context-dependent control.
  4. N-terminus verified by Edman degradation on complete protein
    Title: Escherichia coli PII protein: purification, crystallization and oligomeric structure.
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Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of nitrogen utilization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
nitrogen regulatory protein PII-1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2687070..2687408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417048.1 nitrogen regulatory protein PII-1

    See identical proteins and their annotated locations for NP_417048.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S0FN04
    Conserved Domains (1) summary
    PRK10858
    Location:1 → 112
    PRK10858; nitrogen regulatory protein P-II
Nucleotide Protein
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