glnB [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: glnB
Primary source: ECOCYC:EG10384
Locus tag: b2553
See related: ASAP:ABE-0008398
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK2550
Summary: GlnB is the archetypal PII protein; a ubiquitous family of small trimeric signal transduction proteins that facilitate regulation of bacterial nitrogen metabolism by controlling the activities of a variety of enzymes, transcription factors and membrane proteins. [More information is available at EcoGene: EG10384]. The protein PII plays a critical role in the regulation of nitrogen metabolism by controlling the level and activity of glutamine synthetase. [More information is available at EcoCyc: EG10384].
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NC_000913.3 Genomic Context describing neighboring genes

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We provide evidence here that NanE, GlcNAc-6P epimerase, and the uridylylated PII protein allosterically activate NagB by direct protein-protein interactions.
Title: The Nitrogen Regulatory PII Protein (GlnB) and N-Acetylglucosamine 6-Phosphate Epimerase (NanE) Allosterically Activate Glucosamine 6-Phosphate Deaminase (NagB) in Escherichia coli.
propose that the GlnB protein acts as a 2-oxoglutarate-sensitive dissociable regulatory subunit of acetyl-CoA carboxylase enzyme
Title: The bacterial signal transduction protein GlnB regulates the committed step in fatty acid biosynthesis by acting as a dissociable regulatory subunit of acetyl-CoA carboxylase.
Data show a subtle interplay between GlnB and GlnK.
Title: The pivotal regulator GlnB of Escherichia coli is engaged in subtle and context-dependent control.
N-terminus verified by Edman degradation on complete protein
Title: Escherichia coli PII protein: purification, crystallization and oligomeric structure.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme activator activity	IDA Inferred from Direct Assay more info	PubMed
enables enzyme regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables enzyme regulator activity	IEA Inferred from Electronic Annotation more info
enables enzyme regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small molecule binding	IDA Inferred from Direct Assay more info	PubMed
enables small molecule binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of fatty acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of nitrogen utilization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of nitrogen utilization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of nitrogen utilization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain