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hcaC putative 3-phenylpropionate/cinnamate dioxygenase ferredoxin subunit [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947015, updated on 4-Feb-2026
Official Symbol
hcaC
Official Full Name
putative 3-phenylpropionate/cinnamate dioxygenase ferredoxin subunit
Primary source
ECOCYC:G7334
Locus tag
b2540
See related
ASAP:ABE-0008359
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2537; hcaa3; phdB; yfhW
Summary
Hydrocinnamic acid is a synonym for 3-phenylpropionic acid. [More information is available at EcoGene: EG13458]. Based on sequence similarity, HcaC is thought to encode the ferredoxin component of the 3-phenylpropionate dioxygenase system . [More information is available at EcoCyc: G7334].
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Sequence:
NC_000913.3 (2670908..2671228)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein IroK Neighboring gene DNA-binding transcriptional dual regulator HcaR Neighboring gene putative 3-phenylpropionate/cinnamate dioxygenase subunit alpha Neighboring gene putative 3-phenylpropionate/cinnamate dioxygenase subunit beta Neighboring gene 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase Neighboring gene putative 3-phenylpropionate/cinnamate dioxygenase ferredoxin reductase subunit Neighboring gene putative inner membrane protein

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. 3-phenylpropionate catabolism and the Escherichia coli oxidative stress response. Turlin E, et al. Res Microbiol, 2005 Apr. PMID 15808934
  2. Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation. Burlingame RP, et al. J Bacteriol, 1986 Oct. PMID 3531186, Free PMC Article
  3. Characterization of the recombinant Rieske [2Fe-2S] proteins HcaC and YeaW from E. coli. Boxhammer S, et al. Biometals, 2008 Aug. PMID 18286376
  4. Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12. Díaz E, et al. J Bacteriol, 1998 Jun. PMID 9603882, Free PMC Article
  5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2 iron, 2 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 2 iron, 2 sulfur cluster binding ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables 3-phenylpropionate dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 3-phenylpropionate catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within 3-phenylpropionate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in 3-phenylpropionate catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
Preferred Names
putative 3-phenylpropionate/cinnamate dioxygenase ferredoxin subunit
NP_417035.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2670908..2671228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417035.1 putative 3-phenylpropionate/cinnamate dioxygenase ferredoxin subunit

    See identical proteins and their annotated locations for NP_417035.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A836NCQ4
    Conserved Domains (1) summary
    PRK09965
    Location:1 → 106
    PRK09965; 3-phenylpropionate dioxygenase ferredoxin subunit; Provisional
Nucleotide Protein
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