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glrK histidine kinase GlrK [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947013, updated on 19-Nov-2025
Official Symbol
glrK
Official Full Name
histidine kinase GlrK
Primary source
ECOCYC:G7345
Locus tag
b2556
See related
ASAP:ABE-0008409
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2553; qseE; yfhK; yfhZ
Summary
Characterized in an EPEC strain, QseC activates transcription of qseEGF in response to the autoinducer-3 (AI-3)/epinephrine/norepinephrine interkingdom signaling system (Reading, 2007). [More information is available at EcoGene: EG13461]. Purified YfhK can transphosphorylate its cognate response regulator YfhA in vitro . [More information is available at EcoCyc: G7345].
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Sequence:
NC_000913.3 (2689671..2691098, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene nitrogen regulatory protein PII-1 Neighboring gene DNA-binding transcriptional activator GlrR Neighboring gene outer membrane lipoprotein QseG Neighboring gene ncRNA Neighboring gene phosphoribosylformylglycinamide synthetase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Characterization of the sensor domain of QseE histidine kinase from Escherichia coli. Yeo KJ, et al. Protein Expr Purif, 2016 Oct. PMID 27371359
  2. Small RNA-binding protein RapZ mediates cell envelope precursor sensing and signaling in Escherichia coli. Khan MA, et al. EMBO J, 2020 Mar 16. PMID 32065419, Free PMC Article
  3. Genomic analysis of the histidine kinase family in bacteria and archaea. Kim DJ, et al. Microbiology (Reading), 2001 May. PMID 11320123
  4. Interaction of lipoprotein QseG with sensor kinase QseE in the periplasm controls the phosphorylation state of the two-component system QseE/QseF in Escherichia coli. Göpel Y, et al. PLoS Genet, 2018 Jul. PMID 30040820, Free PMC Article
  5. Compilation of all genes encoding two-component phosphotransfer signal transducers in the genome of Escherichia coli. Mizuno T. DNA Res, 1997 Apr 28. PMID 9205844

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study reveal a three-component signaling system in E. coli K-12, in which membrane-bound QseE is stimulated through interaction with periplasmic QseG to phosphorylate cytoplasmic QseF.
    Title: Interaction of lipoprotein QseG with sensor kinase QseE in the periplasm controls the phosphorylation state of the two-component system QseE/QseF in Escherichia coli.
  2. QseE and QseF are involved in the transcriptional control of genes necessary for pedestal formation
    Title: The two-component system QseEF and the membrane protein QseG link adrenergic and stress sensing to bacterial pathogenesis.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphorelay response regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphorelay sensor kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphorelay sensor kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, carboxyl group as acceptor IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein histidine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein histidine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular chemical homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in osmosensory signaling via phosphorelay pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within peptidyl-histidine phosphorylation ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to epinephrine IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in outer membrane-bounded periplasmic space ISM
Inferred from Sequence Model
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Preferred Names
histidine kinase GlrK
NP_417051.2

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2689671..2691098 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417051.2 histidine kinase GlrK

    See identical proteins and their annotated locations for NP_417051.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S7CLI5
    Conserved Domains (1) summary
    COG0642
    Location:148 → 469
    BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version

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