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nlpD murein hydrolase activator NlpD [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947011, updated on 19-Nov-2025
Official Symbol
nlpD
Official Full Name
murein hydrolase activator NlpD
Primary source
ECOCYC:EG12111
Locus tag
b2742
See related
ASAP:ABE-0009004
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2737
Summary
NlpD in Escherichia coli is similar in sequence to the LppB lipoprotein outer membrane antigen of Haemophilus somnus, a putative virulence determinant. [More information is available at EcoCyc: EG12111].
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Sequence:
NC_000913.3 (2867614..2868753, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transporter YgbN Neighboring gene RNA polymerase sigma factor RpoS Neighboring gene protein-L-isoaspartate O-methyltransferase Neighboring gene broad specificity 5'(3')-nucleotidase and polyphosphatase Neighboring gene tRNA pseudouridine(13) synthase Neighboring gene 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Glutathione production by efficient ATP-regenerating Escherichia coli mutants. Hara KY, et al. FEMS Microbiol Lett, 2009 Aug. PMID 19552708
  2. Identification of transcriptional start sites and the role of ppGpp in the expression of rpoS, the structural gene for the sigma S subunit of RNA polymerase in Escherichia coli. Lange R, et al. J Bacteriol, 1995 Aug. PMID 7642494, Free PMC Article
  3. The nlpD gene is located in an operon with rpoS on the Escherichia coli chromosome and encodes a novel lipoprotein with a potential function in cell wall formation. Lange R, et al. Mol Microbiol, 1994 Aug. PMID 7997184
  4. A fail-safe mechanism in the septal ring assembly pathway generated by the sequential recruitment of cell separation amidases and their activators. Peters NT, et al. J Bacteriol, 2011 Sep. PMID 21764913, Free PMC Article
  5. Structure of the 5' upstream region and the regulation of the rpoS gene of Escherichia coli. Takayanagi Y, et al. Mol Gen Genet, 1994 Jun 3. PMID 8208244

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structure-function analysis revealed that the outer membrane localization of NlpD is critical for regulating its amidase activation activity.
    Title: NlpD links cell wall remodeling and outer membrane invagination during cytokinesis in Escherichia coli.
  2. The authors report that AmiB and EnvC are recruited to division sites independently of one another. The same is also true for AmiC and NlpD.
    Title: A fail-safe mechanism in the septal ring assembly pathway generated by the sequential recruitment of cell separation amidases and their activators.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
murein hydrolase activator NlpD

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2867614..2868753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417222.1 murein hydrolase activator NlpD

    See identical proteins and their annotated locations for NP_417222.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8E0FNL0
    Conserved Domains (1) summary
    PRK10871
    Location:1 → 379
    nlpD; murein hydrolase activator NlpD
Nucleotide Protein
Heading Accession and Version

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