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hcaE putative 3-phenylpropionate/cinnamate dioxygenase subunit alpha [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946998, updated on 26-Mar-2025
Official Symbol
hcaE
Official Full Name
putative 3-phenylpropionate/cinnamate dioxygenase subunit alpha
Primary source
ECOCYC:M009
Locus tag
b2538
See related
ASAP:ABE-0008355
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
digA; ECK2535; hcaA; hcaA1; phdC1; yfhU
Summary
Hydrocinnamic acid is a synonym for 3-phenylpropionic acid. [More information is available at EcoGene: EG13456].
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Sequence:
NC_000913.3 (2669032..2670393)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene stationary phase-inducible protein CsiE Neighboring gene putative 3-phenylpropionate transporter Neighboring gene protein IroK Neighboring gene DNA-binding transcriptional dual regulator HcaR Neighboring gene putative 3-phenylpropionate/cinnamate dioxygenase subunit beta Neighboring gene putative 3-phenylpropionate/cinnamate dioxygenase ferredoxin subunit Neighboring gene 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase Neighboring gene putative 3-phenylpropionate/cinnamate dioxygenase ferredoxin reductase subunit

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. 3-phenylpropionate catabolism and the Escherichia coli oxidative stress response. Turlin E, et al. Res Microbiol, 2005 Apr. PMID 15808934
  2. Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli. Burlingame R, et al. J Bacteriol, 1983 Jul. PMID 6345502, Free PMC Article
  3. Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation. Burlingame RP, et al. J Bacteriol, 1986 Oct. PMID 3531186, Free PMC Article
  4. Proteome analysis of Escherichia coli using high-performance liquid chromatography and Fourier transform ion cyclotron resonance mass spectrometry. Ihling C, et al. Proteomics, 2005 May. PMID 15852340
  5. Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12. Díaz E, et al. J Bacteriol, 1998 Jun. PMID 9603882, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 3-phenylpropionate dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 3-phenylpropionate catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within 3-phenylpropionate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in 3-phenylpropionate catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of 3-phenylpropionate dioxygenase complex NAS
Non-traceable Author Statement
more info
 PubMed 
Preferred Names
putative 3-phenylpropionate/cinnamate dioxygenase subunit alpha
NP_417033.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2669032..2670393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417033.1 putative 3-phenylpropionate/cinnamate dioxygenase subunit alpha [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417033.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6C9QDD9
    Conserved Domains (2) summary
    cd08881
    Location:184 → 433
    RHO_alpha_C_NDO-like; C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases
    COG4638
    Location:16 → 448
    HcaE; Phenylpropionate dioxygenase or related ring-hydroxylating dioxygenase, large terminal subunit [Inorganic ion transport and metabolism, General function prediction only]
Nucleotide Protein
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