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sseA 3-mercaptopyruvate sulfurtransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946993, updated on 19-Feb-2025

Summary

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Official Symbol
sseA
Official Full Name
3-mercaptopyruvate sulfurtransferase
Primary source
ECOCYC:EG11600
Locus tag
b2521
See related
ASAP:ABE-0008299
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2517; mstA
Summary
The sseA gene encodes a 3-mercaptopyruvate:cyanide sulfurtransferase (MST), a rhodanese-like enzyme that, in contrast to rhodanese, uses 3-mercaptopyruvate as the preferred sulfur donor . [More information is available at EcoCyc: EG11600].
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Genomic context

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Sequence:
NC_000913.3 (2652494..2653339)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene peptidoglycan glycosyltransferase PbpC Neighboring gene alpha2-macroglobulin Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene putative toxic protein TimP

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mechanism of H(2)S-mediated protection against oxidative stress in Escherichia coli. Mironov A, et al. Proc Natl Acad Sci U S A, 2017 Jun 6. PMID 28533366, Free PMC Article
  2. H2S: a universal defense against antibiotics in bacteria. Shatalin K, et al. Science, 2011 Nov 18. PMID 22096201
  3. The "rhodanese" fold and catalytic mechanism of 3-mercaptopyruvate sulfurtransferases: crystal structure of SseA from Escherichia coli. Spallarossa A, et al. J Mol Biol, 2004 Jan 9. PMID 14672665
  4. SseA, a 3-mercaptopyruvate sulfurtransferase from Escherichia coli: crystallization and preliminary crystallographic data. Spallarossa A, et al. Acta Crystallogr D Biol Crystallogr, 2003 Jan. PMID 12499560
  5. Properties of the Escherichia coli rhodanese-like protein SseA: contribution of the active-site residue Ser240 to sulfur donor recognition. Colnaghi R, et al. FEBS Lett, 2001 Jul 6. PMID 11445076

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3-mercaptopyruvate sulfurtransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-mercaptopyruvate sulfurtransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-mercaptopyruvate sulfurtransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables sulfurtransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables thiosulfate-cyanide sulfurtransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thiosulfate-cyanide sulfurtransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables thiosulfate-cyanide sulfurtransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA protection IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to antibiotic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
3-mercaptopyruvate sulfurtransferase
NP_417016.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2652494..2653339
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417016.4 3-mercaptopyruvate sulfurtransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417016.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2X1MCH6
    Conserved Domains (1) summary
    PRK11493
    Location:1 → 281
    sseA; 3-mercaptopyruvate sulfurtransferase; Provisional
Nucleotide Protein
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