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purM phosphoribosylformylglycinamide cyclo-ligase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946975, updated on 30-Jul-2025
Official Symbol
purM
Official Full Name
phosphoribosylformylglycinamide cyclo-ligase
Primary source
ECOCYC:EG10798
Locus tag
b2499
See related
ASAP:ABE-0008230
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2495; purG; purI
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Sequence:
NC_000913.3 (2621197..2622234)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene uracil:H(+) symporter UraA Neighboring gene uracil phosphoribosyltransferase Neighboring gene phosphoribosylglycinamide formyltransferase 1 Neighboring gene polyphosphate kinase Neighboring gene exopolyphosphatase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Purification and characterization of aminoimidazole ribonucleotide synthetase from Escherichia coli. Schrimsher JL, et al. Biochemistry, 1986 Jul 29. PMID 3530323
  2. Identification of the enzymatic reactions encoded by the purG and purI genes of Escherichia coli. Houlberg U, et al. J Bacteriol, 1983 Jun. PMID 6343356, Free PMC Article
  3. Characterization of the upp gene encoding uracil phosphoribosyltransferase of Escherichia coli K12. Andersen PS, et al. Eur J Biochem, 1992 Feb 15. PMID 1371255
  4. Nucleotide sequence of the purM gene encoding 5'-phosphoribosyl-5-aminoimidazole synthetase of Escherichia coli K12. Smith JM, et al. J Biol Chem, 1986 Aug 15. PMID 3015935
  5. P-BOSS: a new filtering method for treasure hunting in metabolomics. Morohashi M, et al. J Chromatogr A, 2007 Aug 3. PMID 17400234

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosylamine-glycine ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoribosylformylglycinamidine cyclo-ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoribosylformylglycinamidine cyclo-ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoribosylformylglycinamidine cyclo-ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in adenine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in purine nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in purine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
phosphoribosylformylglycinamide cyclo-ligase
NP_416994.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2621197..2622234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416994.1 phosphoribosylformylglycinamide cyclo-ligase

    See identical proteins and their annotated locations for NP_416994.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2H4TWM0
    Conserved Domains (1) summary
    PRK05385
    Location:7 → 333
    PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
Nucleotide Protein
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