U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

hyfA hydrogenase 4 component A [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946959, updated on 23-Apr-2026
Official Symbol
hyfA
Official Full Name
hydrogenase 4 component A
Primary source
ECOCYC:EG11150
Locus tag
b2481
See related
ASAP:ABE-0008179
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2477; yffE
Summary
This subunit contains four 4Fe-4S clusters and may be involved in electron transfer. [More information is available at EcoCyc: EG11150].
Try the new Gene page
Try the new Transcripts and proteins table
Sequence:
NC_000913.3 (2601201..2601818)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 4-hydroxy-tetrahydrodipicolinate synthase Neighboring gene transcriptional regulator GcvR Neighboring gene thiol peroxidase Neighboring gene hydrogenase 4 component B Neighboring gene hydrogenase 4 component C

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A molecular analysis of the 53.3 minute region of the Escherichia coli linkage map. Andrews SC, et al. J Gen Microbiol, 1991 Feb. PMID 2016588
  2. Participation of hyf-encoded hydrogenase 4 in molecular hydrogen release coupled with proton-potassium exchange in Escherichia coli. Bagramyan K, et al. Membr Cell Biol, 2001. PMID 11817571
  3. Phosphorylation of ribosomal proteins in HeLa cells infected with vaccinia virus. Kaerlein M, et al. Nature, 1976 Jan 15. PMID 1246353
  4. Expression and regulation of a silent operon, hyf, coding for hydrogenase 4 isoenzyme in Escherichia coli. Self WT, et al. J Bacteriol, 2004 Jan. PMID 14702328, Free PMC Article
  5. Quantitative whole-genome analysis of DNA-protein interactions by in vivo methylase protection in E. coli. Tavazoie S, et al. Nat Biotechnol, 1998 Jun. PMID 9624689

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Component Evidence Code Pubs
part_of [Ni-Fe] hydrogenase complex RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Preferred Names
hydrogenase 4 component A

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2601201..2601818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416976.4 hydrogenase 4 component A

    See identical proteins and their annotated locations for NP_416976.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7L7EHY9
    Conserved Domains (1) summary
    cd10554
    Location:4 → 170
    HycB_like; HycB, HydN and similar proteins
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.