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grxB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946926, updated on 11-Sep-2024

Summary

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Official Symbol
grxB
Primary source
ECOCYC:EG12688
Locus tag
b1064
See related
ASAP:ABE-0003615
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1049
Summary
Glutaredoxins are ubiquitous proteins that catalyze the reduction of disulfides via reduced glutathione (GSH). [More information is available at EcoCyc: EG12688].
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Genomic context

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Sequence:
NC_000913.3 (1123407..1124054, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene dihydroorotase Neighboring gene putative lipid-binding lipoprotein YceB Neighboring gene multidrug efflux pump MdtH Neighboring gene ribosomal-protein-S5-alanine N-acetyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Stability and unfolding of reduced Escherichia coli glutaredoxin 2: a monomeric structural homologue of the glutathione transferase family. Gildenhuys S, et al. Biochemistry, 2008 Oct 7. PMID 18788752
  2. Crystallization and preliminary X-ray crystallographic analysis of Escherichia coliglutaredoxin 2 in complex with glutathione and of a cysteine-less variant without glutathione. Sheng J, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2007 Apr 1. PMID 17401194, Free PMC Article
  3. Expression of Escherichia coli glutaredoxin 2 is mainly regulated by ppGpp and sigmaS. Potamitou A, et al. J Biol Chem, 2002 May 17. PMID 11889138
  4. Reactivity of glutaredoxins 1, 2, and 3 from Escherichia coli shows that glutaredoxin 2 is the primary hydrogen donor to ArsC-catalyzed arsenate reduction. Shi J, et al. J Biol Chem, 1999 Dec 17. PMID 10593884
  5. Cloning, overexpression, and characterization of glutaredoxin 2, an atypical glutaredoxin from Escherichia coli. Vlamis-Gardikas A, et al. J Biol Chem, 1997 Apr 25. PMID 9111025

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Two additional glutaredoxins exist in Escherichia coli: glutaredoxin 3 is a hydrogen donor for ribonucleotide reductase in a thioredoxin/glutaredoxin 1 double mutant.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables glutathione disulfide oxidoreductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
reduced glutaredoxin 2
NP_415582.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1123407..1124054 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415582.1 reduced glutaredoxin 2 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415582.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6M9WX06, A0A8S7BIW5, A0A8S7EM69
    Conserved Domains (1) summary
    PRK10387
    Location:1 → 210
    PRK10387; glutaredoxin 2; Provisional
Nucleotide Protein
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