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grxB reduced glutaredoxin 2 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946926, updated on 6-Jul-2026
Official Symbol
grxB
Official Full Name
reduced glutaredoxin 2
Primary source
ECOCYC:EG12688
Locus tag
b1064
See related
ASAP:ABE-0003615
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1049
Summary
Glutaredoxins are ubiquitous proteins that catalyze the reduction of disulfides via reduced glutathione (GSH). [More information is available at EcoCyc: EG12688].
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Sequence:
NC_000913.3 (1123407..1124054, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene dihydroorotase Neighboring gene putative lipid-binding lipoprotein YceB Neighboring gene multidrug efflux pump MdtH Neighboring gene ribosomal-protein-S5-alanine N-acetyltransferase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Stability and unfolding of reduced Escherichia coli glutaredoxin 2: a monomeric structural homologue of the glutathione transferase family. Gildenhuys S, et al. Biochemistry, 2008 Oct 7. PMID 18788752
  2. Crystallization and preliminary X-ray crystallographic analysis of Escherichia coliglutaredoxin 2 in complex with glutathione and of a cysteine-less variant without glutathione. Sheng J, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2007 Apr 1. PMID 17401194, Free PMC Article
  3. Expression of Escherichia coli glutaredoxin 2 is mainly regulated by ppGpp and sigmaS. Potamitou A, et al. J Biol Chem, 2002 May 17. PMID 11889138
  4. Cloning, overexpression, and characterization of glutaredoxin 2, an atypical glutaredoxin from Escherichia coli. Vlamis-Gardikas A, et al. J Biol Chem, 1997 Apr 25. PMID 9111025
  5. Reactivity of glutaredoxins 1, 2, and 3 from Escherichia coli shows that glutaredoxin 2 is the primary hydrogen donor to ArsC-catalyzed arsenate reduction. Shi J, et al. J Biol Chem, 1999 Dec 17. PMID 10593884

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Two additional glutaredoxins exist in Escherichia coli: glutaredoxin 3 is a hydrogen donor for ribonucleotide reductase in a thioredoxin/glutaredoxin 1 double mutant.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione disulfide oxidoreductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
reduced glutaredoxin 2
NP_415582.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1123407..1124054 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415582.1 reduced glutaredoxin 2

    See identical proteins and their annotated locations for NP_415582.1

    Status: REVIEWED

    Conserved Domains (1) summary
    PRK10387
    Location:1 → 210
    PRK10387; glutaredoxin 2; Provisional
Nucleotide Protein
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