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bisC biotin sulfoxide reductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946915, updated on 9-Mar-2022

Summary

Gene symbol
bisC
Gene description
biotin sulfoxide reductase
Primary source
ASAP:ABE-0011597
Locus tag
b3551
See related
ECOCYC:EG10124
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3538
Summary
BisC is sufficient for growth on Met-S-SO. [More information is available at EcoGene: EG10124]. BisC was first identified as a biotin sulfoxide reductase that reduces a spontaneous oxidation product of biotin, biotin d-sulfoxide (BDS), back to biotin. [More information is available at EcoCyc: EG10124].
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Genomic context

Sequence:
NC_000913.3 (3714061..3716394, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative outer membrane protein YhjY Neighboring gene 3-methyl-adenine DNA glycosylase I, constitutive Neighboring gene peptidyl-lysine N-acetyltransferase YiaC Neighboring gene PF13488 family lipoprotein YiaD Neighboring gene glyoxylate reductase

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables L-methionine:thioredoxin-disulfide S-oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables L-methionine:thioredoxin-disulfide S-oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables electron transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molybdenum ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molybdenum ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables molybdopterin cofactor binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in anaerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in electron transport chain IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in outer membrane-bounded periplasmic space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
biotin sulfoxide reductase
NP_418007.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3714061..3716394 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418007.3 biotin sulfoxide reductase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418007.3

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P20099
    Conserved Domains (1) summary
    TIGR00509
    Location:13775
    bisC_fam; molybdopterin guanine dinucleotide-containing S/N-oxide reductases