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hemF coproporphyrinogen III oxidase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946908, updated on 19-Sep-2024

Summary

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Official Symbol
hemF
Official Full Name
coproporphyrinogen III oxidase
Primary source
ECOCYC:EG12189
Locus tag
b2436
See related
ASAP:ABE-0008034
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2431; popB; sec
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Genomic context

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Sequence:
NC_000913.3 (2553225..2554124)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative inner membrane protein Neighboring gene putative acetyltransferase YpeA Neighboring gene N-acetylmuramoyl-L-alanine amidase A Neighboring gene putative DNA-binding transcriptional regulator EutR Neighboring gene putative structural protein, ethanolamine utilization microcompartment

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The induction of two biosynthetic enzymes helps Escherichia coli sustain heme synthesis and activate catalase during hydrogen peroxide stress. Mancini S, et al. Mol Microbiol, 2015 May. PMID 25664592, Free PMC Article
  2. Oxygen-dependent coproporphyrinogen-III oxidase from Escherichia coli: one-step purification and biochemical characterisation. Macieira S, et al. FEMS Microbiol Lett, 2003 Sep 12. PMID 13129604
  3. Oxygen-dependent coproporphyrinogen III oxidase (HemF) from Escherichia coli is stimulated by manganese. Breckau D, et al. J Biol Chem, 2003 Nov 21. PMID 12975365
  4. Identification and characterization of hydrogen peroxide-sensitive mutants of Escherichia coli: genes that require OxyR for expression. Mukhopadhyay S, et al. J Bacteriol, 1997 Jan. PMID 8990283, Free PMC Article
  5. Cloning and characterization of the Escherichia coli hemN gene encoding the oxygen-independent coproporphyrinogen III oxidase. Troup B, et al. J Bacteriol, 1995 Jun. PMID 7768836, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables coproporphyrinogen oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables coproporphyrinogen oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables coproporphyrinogen oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables coproporphyrinogen oxidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables manganese ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables tetrapyrrole binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within heme biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in porphyrin-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protoporphyrinogen IX biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protoporphyrinogen IX biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protoporphyrinogen IX biosynthetic process from glutamate EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within response to hydroperoxide IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to hydroperoxide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
coproporphyrinogen III oxidase
NP_416931.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2553225..2554124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416931.1 coproporphyrinogen III oxidase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416931.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0E2L2S8, A0A0H3EM02, A0A192C9I3, A0A1V1GAW9, A0A7H4YLG3, A0A8S7E9P6, A0AA36KZD7, F4T1N1, Q1R8T5, S1PYB0
    Conserved Domains (1) summary
    PRK05330
    Location:1 → 299
    PRK05330; oxygen-dependent coproporphyrinogen oxidase
Nucleotide Protein
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